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　　1992年山東大學(xué)微生物系微生物學(xué)專業(yè)畢業(yè)，獲理學(xué)學(xué)士學(xué)位;2001年北京大學(xué)生命科學(xué)院分子細(xì)胞生物學(xué)專業(yè)畢業(yè)，獲理學(xué)博士學(xué)位;2001-2004年在美國(guó)哈佛大學(xué)醫(yī)學(xué)院從事博士后研究工作;2004-2008年在美國(guó)德州大學(xué)西南醫(yī)學(xué)中心從事博士后研究工作。2008年6月起任中科院上海生科院生物化學(xué)與細(xì)胞生物學(xué)研究所(現(xiàn)中國(guó)科學(xué)院分子細(xì)胞科學(xué)卓越創(chuàng)新中心)研究員，研究組長(zhǎng)。

　　細(xì)胞是生命活動(dòng)的基本單元，細(xì)胞的生長(zhǎng)、增殖、分化、機(jī)體發(fā)育以及對(duì)環(huán)境刺激的應(yīng)答，代謝水平的維持等基本生命活動(dòng)均受到多種細(xì)胞內(nèi)外信號(hào)的動(dòng)態(tài)調(diào)控。細(xì)胞感受細(xì)胞內(nèi)外多種信號(hào)，協(xié)調(diào)機(jī)體內(nèi)周圍的細(xì)胞做出特定的反應(yīng)，是機(jī)體生命活動(dòng)的基礎(chǔ)。而相關(guān)調(diào)控的異常也將導(dǎo)致包括發(fā)育疾病、癌癥、代謝類疾病在內(nèi)的多種嚴(yán)重疾病的發(fā)生。深入理解細(xì)胞內(nèi)在調(diào)控規(guī)律是理解細(xì)胞的正常功能以及人工干預(yù)和糾正細(xì)胞病理狀態(tài)下異常功能的基礎(chǔ)。

　　聚焦上述科學(xué)問(wèn)題，實(shí)驗(yàn)室綜合利用細(xì)胞生物學(xué)、發(fā)育生物學(xué)、生物化學(xué)、分子生物學(xué)、遺傳學(xué)等技術(shù)手段和方法，在分子、細(xì)胞、組織、器官及動(dòng)物整體等多個(gè)層次研究相關(guān)信號(hào)通路的分子調(diào)控機(jī)制以及其在機(jī)體組織器官發(fā)育、代謝、干細(xì)胞干性維持、腫瘤發(fā)生發(fā)展及腫瘤免疫中的生物學(xué)功能。

1. Jiayin Peng,?Lili Han,?Biao Liu,?Jiawen Song,?Yuang Wang,?Kunpeng Wang,?Qian Guo,?XinYan Liu,?Yu Li,?Jujin Zhang,?Wenqing Wu,?Sheng Li,?Xin Fu,?Cheng-le Zhuang,?Weikang Zhang,?Shengbao Suo,?Ping Hu*?and Yun Zhao*.?Gli1 marks a sentinel muscle stem cell population for muscle regeneration.?Nature Communication.?2023, 14, 6993.doi: 10.1038/s41467-023-42837-8. (* co-corresponding author)
2. Chaoxiong Wang, Xichen Zheng, Jinlan Zhang, Xiaoyi Jiang, Jia Wang, Yuwei Li, Xiaonan Li, Guanghui Shen, Jiayin Peng, Peixuan Zheng, Yunqing Gu, Jiaojiao Chen, Mobin Lin, Changwen Deng, Hai Gao*, Zhigang Lu*, Yun Zhao*, Min Luo*. CD300ld on neutrophils is required for tumor-driven immune suppression. Nature. 2023, Sep. Doi:10.1038/s41586-023-06511-9. Online ahead of print. (* co-corresponding author)
3. Li Zhang, Lingpu Zhang, Yuqi Wang, Kai Jiang, Chao Gao, Pengfei Zhang, Yujie Xie, Bin Wang, Yun Zhao, Haihua Xiao and Jie Song. Regulating the Surface Topography of CpG Nanoadjuvant via Coordination-Driven Self-assembly for Enhanced Tumor Immunotherapy. Nanoscale Advances. 2023, Aug., DOI: 10.1039/d3na00322. Online ahead of print.
4. Zhenyang Guo,?Xueting Yu,?Shuang Zhao,?Xin Zhong,?Dong Huang,?Runyang Feng,?Peng Li,?Zheyan Fang,?Yiqing Hu,?Zhentao Zhang,?Mukaddas Abdurahman,?Lei Huang,?Yun Zhao,?Xiangdong Wang,?Junbo Ge and?Hua Li. SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter. Clinical and Translational Medicine. 2023; Aug; 13(8):e1377.?doi: 10.1002/ctm2.1377.
5. Yehua Li, Jiayin Peng*, Yuanxin Xia, Chenyu Pan, Yu Li, Weijie Gu, Jia Wang, Chaoxiong Wang, Yuang Wang, Jiawen Song, Xuan Zhou, Liya Ma, Yiao Jiang, Biao Liu, Qiongni Feng, Wenjia Wang, Shi Jiao, Liwei An, Dianfan Li, Zhaocai Zhou* and Yun Zhao*. Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6. Theranostics.?2023; Jun; 13(11):3761-3780. doi:10.7150/thno.83676. (* co-corresponding author)
6. Guoqing Cai,?Yijun Qi,?Ping Wei,?Hong Gao,?Chenqi Xu,?Yun Zhao,?Xiujuan Qu,?Feng Yao and?Weiwei Yang. IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis. Advanced Science. 2023 Jul;10(21):e2206540. doi: 10.1002/advs.202206540.
7. Wencheng Zhu,?Huiying Chu,?Yajuan Zhang, Tianhang Luo,?Hua Yu,?Hongwen Zhu,?Ye Liu,?Hong Gao,?Yun Zhao,?Quanlin Li, Xiongjun Wang,?Guohui Li?&?Weiwei Yang. Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis. Cell Research. 2023 Mar;33(3):245-257. doi: 10.1038/s41422-022-00773-0..
8. Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou, Yun Zhao*. Chromosome territory reorganization through artificial chromosome fusion is negligible to cell fate determination and mouse development. Cell Discovery. 2023 Jan 24;9(1):11. doi: 10.1038/s41421-022-00511-1.
9. Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou, Yun Zhao*. Chromosome territory reorganization through artificial chromosome fusion is negligible to cell fate determination and mouse development. 2022; BioRxiv. doi:10.1101/2022.10.09.511475.
10. Jiayin Peng, Fei Li, Jia Wang, Chaoxiong Wang, Yiao Jiang, Biao Liu, Juan He, Kai Yuan, Chenyu Pan, Moubin Lin, Bin Zhou, Luonan Chen, Dong Gao*, Yun Zhao*. Identification of a rare Gli1⁺ progenitor cell population contributing to liver regeneration during chronic injury. Cell Discovery. 2022 Nov 1; 8(1):118.?doi: 10.1038/s41421-022-00474-3.
11. Yajuan Zhang,?Ming Zhao,?Hong Gao,?Guanzhen Yu,?Yun Zhao*,?Feng Yao*?and Weiwei Yang*.?MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion. Nature Metabolism. 2022; Mar 4; 3:374-388.
12. Yunqing Gu, Jun Cao, Xinyu Zhang, Hai Gao, Yuyan Wang, Jia Wang, Juan He, Jinlan Zhang, Guanghui Shen, Jie Yang, Xichen Zheng, Gaowei Hu, Yuanfei Zhu, Shujuan Du, Yunkai Zhu, Rong Zhang, Jianqing Xu, Fei Lan, Di Qu, Yun Zhao*, Guoliang Xu*, Dong Gao*, Youhua Xie*, Min Luo* and Zhigang Lu*. Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Research. 2022; Jan 32; 1:24-37. doi: 10.1038/s41422-021-00595-6.
13. Huihong Jiang,?Erjiang Tang,?Ying Chen,?Hailong Liu,?Yun Zhao*,?Moubin Lin*?and Luwei He*. Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Cancer Science. 2022; Mar 07; 113:971-985?doi: 10.1111/cas.15248.
14. Yiao Jiang, Jiayin Peng, Jiawen Song, Juan He, Man Jiang, Jia Wang, Liya Ma, Yuang Wang, Moubin Lin, Hailong Wu, Zhao Zhang, Dong Gao, Yun Zhao*. Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2. Nature Metabolism. 2021; Nov;3(11):1569-1584. doi: 10.1038/s42255-021-00488-3.?
15. Yitian Luo,?Guoyue Wan,?Xuan Zhou,?Qiuwen Wang,?Yunbin Zhang,?Juan Bao,?Yao Cong,?Yun Zhao*, Dianfan Li*. Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release. Frontiers in Molecular Biosciences. 2021; Sep 7; 8:701826. doi: 10.3389/fmolb.2021.701826.?eCollection 2021.
16. Luwei He*, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao*, Moubin Lin*. Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. Cancer Communications. ?2021; 41(8):726-746.
17. Hui Zhang,?Moubin Lin,?Chao Dong,?Yang Tang,?Liwei An,?Junyi Ju,?Fuping Wen,?Fan Chen,?Meng Wang,?Wenjia Wang,?Min Chen,?Yun Zhao,?Jixi Li,?Steven X Hou,?Xinhua Lin,?Lulu Hu,?Wenbo Bu,?Dianqing Wu,?Lin Li,?Shi Jiao,?Zhaocai Zhou. An MST4-pβ-Catenin?Thr40?Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Advance Science. 2021; e2004850. ?doi: 10.1002/advs.202004850.?
18. Yitian Luo,?Guoyue Wan,?Xiang Zhang,?Xuan Zhou,?Qiuwen Wang,?Jialin Fan,?Hongmin Cai,?Liya Ma,?Hailong Wu,?Qianhui Qu*,?Yao Cong*,?Yun Zhao*,?Dianfan Li*. Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure. 2021; 29(11):1286-1294.
19. Heng Feng?,?Wenhui Xing,?Yujiao Han,?Jun Sun,?Mingxiang Kong?,?Bo Gao,?Yang Yang,?Zi Yin,?Xiao Chen?,?Yun Zhao?,?Qing Bi,?Weiguo Zou. Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. The Journal of Clinical Investigation. 2020; 130(12):6354-6365.
20. Shuo Zhang,?Juan Zhao,?Xiangdong Lv?,?Jialin Fan,?Yi Lu,?Tao Zeng?,?Hailong Wu,?Luonan Chen*?,?Yun Zhao*. Analysis on gene modular network reveals morphogen-directed development robustness in?Drosophila. Cell Discovery. 2020; 6:43. doi: 10.1038/s41421-020-0173-z
21. Yang Tang,?Gemin Fang,?Fenghua Guo,?Hui Zhang,?Xiaoxu Chen,?Liwei An,?Min Chen,?Li Zhou,?Wenjia Wang,?Tiantian Ye,?Lei Zhou,?Pingping Nie,?Haijun Yu,?Moubin Lin,?Yun Zhao,?Xinhua Lin,?Zengqiang Yuan,?Shi Jiao,?Zhaocai Zhou. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020; 38(1):115-128.e9. doi: 10.1016/j.ccell.2020.05.019
22. Ke Zhang, Fang Yu, Jian Zhu, Sue Han, Jiehui Chen, Xuanyuan Wu, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He, Naihe Jing, Ke Tang. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neuro developmental Disorders with an?NR2F1?Point Mutation. Cell Reports.?2020; 21;31(3):107521. doi: 10.1016/j.celrep.2020.03.085
23. Liwei An,?Pingping Nie,?Min Chen,?Yang Tang,?Hui Zhang,?Jingmin Guan,?Zhifa Cao,?Chun Hou,?Wenjia Wang,?Yun Zhao,?Huixiong Xu,?Shi Jiao,?Zhaocai Zhou. MST4 Kinase Suppresses Gastric Tumorigenesis by Limiting YAP Activation via a Non-Canonical Pathway. Journal of Experimental Medicine. 2020; 217(6):e20191817.
24. Xue Feng,?Tiantian Lu,?Jinhui Li, Ruizeng Yang,?Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng, Wei Tian and Lei Zhang. The tumor suppressor Interferon Regulatory Factor 2 Binding Protein 2 regulates Hippo pathway in liver cancer by a feedback loop in mice. Hepatology.?2020; 71(6):1988-2004
25. Ruoying Yu,?Huihui Wu,?Hazrat Ismail?,?Shihao Du?,?Jun Cao,?Jianyu Wang,?Tarsha Ward,?Fengrui Yang,?Ping Gui,?Mahboob Ali,?Lingluo Chu,?Fei Mo,?Qi Wang,?Youjun Chu,?Yun Zhao,?Mingliang Ye,?Guowei Fang,?Peng R Chen,?Zhen Dou,?Xinjiao Gao,?Wenwen Wang,?Xing Liu,?Xuebiao Yao. Methylation of PLK1 by SET7/9 Ensures Accurate Kinetochore-Microtubule Dynamics. Journal of Molecular Cell Biology. 2020; 12(6):462-476.?
26. Jialin Fan, Yajie Gao, Yi Lu, Wenqing Wu, Shuo Yuan, Hailong Wu, Dahua Chen and Yun Zhao*. PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila. Cell Discovery. 2019; 5:44.
27. Lingli?He,?Liang?Yuan,?Yang?Sun,?Pingyang?Wang,?Hailin?Zhang,?Xue?Feng,?Zuoyun?Wang,?Wenxiang?Zhang,?Chuanyu Yang,?Yi Arial Zeng, Yun Zhao, Ceshi Chen and Lei Zhang. Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression. Cancer Research.?2019; 79(17):4399-4411
28. Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu, Lei Zhang. Dual function of VGLL4 in muscle regeneration. EMBO J. 2019; 38:e101051
29. Wei Yu,?Xueyan Ma,?Jinjin Xu,?Andreas Wilhelm Heumüller,?Zhaoliang Fei,?Xue Feng,?Xiaodong Wang, Kuo Liu,?Jinhui Li,?Guizhong Cui,?Guangdun Peng,?Hongbin Ji,?Jinsong Li,?Naihe Jing,?Hai Song,?Zhiqiang Lin,?Yun Zhao, Zuoyun Wang,?Bin Zhou,?and?Lei Zhang. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet. 2019; 15(2):e1007977.
30. Yang Tang,?Min Chen,?Li Zhou,?Jian Ma,?Yehua Li,?Hui Zhang,?Zhubing Shi,?Qi Xu,?Xiaoman Zhang, Ziyang Gao,?Yun Zhao,?Yunfeng Cheng,?Shi Jiao?and?Zhaocai Zhou. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discovery. 2019; 5:3.
31. Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu and Yun Zhao*. Distinct Functions of Polycomb Group Proteins in Regulating?Ci?Transcription in Developing Drosophila. Journal of Molecular Cell Biology. 2018, 10(5):475-478.
32. Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu and Yun Zhao*. Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci). Journal of Molecular Cell Biology. 2018, 10(5):437-447.
33. Wenxiang Zhang,?Jinjin Xu,?Jinhui Li,?Tong Guo,?Dan Jiang,?Xue Feng, Xueyan Ma,?Lingli He,?Wenqing Wu,? Mengxin Yin,?Ling Ge,?Zuoyun Wang, Margaret S. Ho,?Yun Zhao,?Zhaoliang Fei?and?Lei Zhang. The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. Journal of Biological Chemistry.?2018, 293(44):17119-17134.
34. Xueyan Ma,?Peixue Li,?Peihao Chen,?Jinhui Li,?Hongling Huang,?Chao Wang, Wenjing Li, Jianping Ding,?Yun Zhao,?Fa-Xing Yu,?Xiangbing Qi?and Lei Zhang. Staurosporine targets the Hippo pathway to inhibit cell growth. Journal of Molecular Cell Biology. 2018, 10(3):267-269.
35. Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Jialin Fan, Hao Chen, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang and Yun Zhao*. UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing. EMBO Reports. 2017, 18(11):1922-1934.
36. Yuhong Han, Yue Xiong, Xuanming Shi, Jiang Wu, Yun Zhao* and Jin Jiang*. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. PLoS Biology.?2017, 15(8):e2002063.
37. Shuo Zhang,?Chenyu Pan,?Xiangdong Lv,?Wei Wu,?Hao Chen,?Wenqing Wu,?Hailong Wu,?Lei Zhang,?and?Yun Zhao^*. Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult?Drosophila?testis. Scientific Reports. 2017, 7: 5101.
38. Xu Xiao, Jing-jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-ping Qiu, Yue Xiong, Lian-fang Yang, Hai-wei Cui, Xiao-long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-liang Li, Wen-wei Qiu and Bao-liang Song. Cholesterol modification of Smoothened is required for Hedgehog signaling. Molecular Cell.?2017, 66(1):154-162.
39. Jiajun Xu,?Xue Hao,?Meng-Xin Yin,?Yi Lu,?Yunyun Jin,?Jinjin Xu,?Ling Ge,?Wenqing Wu, Margaret Ho,?Yingzi Yang,?Yun Zhao and?Lei Zhang. Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. Development.?2017,?144:?1510-1517.
40. Yi Hao,?Qinbo Zhou,?Jing Ma,?Yun Zhao,?and?Shusheng Wang. miR-146a is upregulated during retinal pigment epithelium (RPE)/choroid aging in mice and represses IL-6 and VEGF-A expression in RPE cells. J Clin Exp Ophthalmol. 2016, 7(3): 562.
41. Lin Fu, Hailong Wu, Steven Y Cheng, Daming Gao, Lei Zhang and Yun Zhao^*. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway. eLIFE. 2016, 5:e15690.
42. Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei^* and Yun Zhao^*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research. 2016, 26:529-542. ?
43. Xiangdong Lv, Chenyu Pan, Zhao Zhang, Yuanxin Xia, Hao Chen, Shuo Zhang, Tong Guo, Hui Han, Haiyun Song, Lei Zhang and Yun Zhao^*. SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis. Development. 2016, 143(10):1655-1662. ?
44. Shimin Wang, Yi Lu, Mengxin Yin, Chao Wang, Wei Wu, Jinhui Li, Wenqing Wu, Lianxin Hu, Yun Zhao and Lei Zhang. Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal. Journal of Biological Chemistry. 2016, 291:7926-7937.
45. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, and Yun Zhao?and Lei Zhang.?Taiman acts as a co-activator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration.?Cell Discovery.?2016, 2:16006.
46. Lianxin Hu, Jiajun Xu, Meng-Xin Yin, Liguo Zhang, Yi Lu, Wenqing Wu, Zhaoyu Xu, Margaret S. Ho, Guanjun Gao, Yun Zhao?and Lei Zhang.?Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.?Cell Discovery.?2016, 2:15047.
47. Hui Han, Jialin Fan, Yue Xiong, Wenqing Wu, Yi Lu, Lei Zhang and Yun Zhao^*. Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription. Scientific Reports. 2016, 6:18937.
48. Hui Wang, Zaijun Ma, Kongyan Niu, Yi Xiao, Xiaofen Wu, Chenyu Pan, Yun Zhao, Kai Wang, Yaoyang Zhang and Nan Liu. Antagonistic roles between Nibbler and Hen1 modulate piRNA 3' ends in Drosophila. Development. 2016, 143(3):530-539.
49. Chunying Liu, Yue Xiong, Jing Feng, Lei Zhang and Yun Zhao^*. Sqh?is involved in the regulation of?Ci?stability in Hh signaling pathway. Journal of Molecular Cell Biology. 2015, 7:584-587. ?
50. Liang Dong,? Jinhui Li,?Hongling Huang,?Meng-Xin Yin,?Jinjin Xu, Peixue Li,?Yi Lu,?Wenqing Wu,?Hang Yang,?Yun Zhao?and Lei Zhang. Growth suppressor lingerer regulates?bantam microRNA to restrict organ size. Journal of Molecular Cell Biology. 2015, 7(5):415-428.
51. Qian?Hao,?Shi?Jiao,?Zhubing?Shi,?Chuanchuan?Li,?Xia?Meng,?Zhen?Zhang,?Yanyan?Wang, Xiaomin?Song,?Wenjia?Wang,?Rongguang?Zhang,?Yun?Zhao,?Catherine CL?Wong and Zhaocai?Zhou. A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO Journal. 2015, 34(23):2903-2920.
52. Zhao Zhang, Yanyan Wang, Chuanchuan Li, Zhubing Shi, Qian Hao, Wenjia Wang, Xiaomin Song, Yun Zhao, Shi Jiao and Zhaocai Zhou. The transitional endoplasmic reticulum ATPase p97 regulates the alternative nuclear factor NF-κB signaling via partial degradation of the NF-κB subunit p100. Journal of Biological Chemistry. 2015, 290(32):19558-19568.
53. Lin Fu, Xiangdong Lv, Yue Xiaong and Yun Zhao^*. Investigation of protein-protein interactions and conformational changes in Hedgehog signaling pathway by FRET. Methods in Molecular Biology, Hedgehog Signaling Protocols (Second Edition, Springer Science). 2015, 1322:61-70.
54. Zizhang Zhou, Xia Yao, Shuang Li, Yue Xiong, Xiaohua Dong, Yun Zhao^#, Jin Jiang^# and Qing Zhang^#. Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling. Developmental Cell. 2015, 34(1):58-72. (#Co-senior author)
55. Hui Han, Chenyu Pan, Chunying Liu, Xiangdong Lv, Xiaofeng Yang, Yue Xiong, Yi Lu, Wenqing Wu, Junhai Han, Zhaocai Zhou, Hai Jiang, Lei Zhang and Yun Zhao^*. Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell Discovery. 2015, 1:15006.
56. Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao and Lei Zhang. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications. 2015, 6:6607.
57. Shi Jiao, Zhen Zhang, Chuanchuan Li, Min Huang, Zhubing Shi, Yanyan Wang, Xiaomin Song, Heng Liu, Chunyang Li, Min Chen, Wenjia Wang, Yun Zhao, Zhengfan Jiang, Hongyan Wang, Catherine C L Wong,?Chen Wang and?Zhaocai Zhou. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.?Nature Immunology. 2015, 16(3):246-257.
58. Yue Xiong, Chunying Liu and Yun Zhao^*. Decoding Ci: from partial degradation to inhibition. Development, Growth & Differentiation. 2015, 57(2):98-108. (invited review)
59. Chuanchuan Li, Miao Feng, Zhubing Shi, Qian Hao, Xiaomin Song, Wenjia Wang, Yun Zhao, Shi Jiao and Zhaocai Zhou. Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1. Journal of Biological Chemistry. 2014, 289(52):35969-35978.
60. Lianxin Hu, Hongling Huang, Jinhui Li, Meng-xin Yin, Yi Lu, Wenqing Wu, Rong Zeng, Jin Jiang, Yun Zhao and Lei Zhang. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress yorkie protein activity for growth control. Journal of Biological Chemistry. 2014, 289(48):33598-33607.?
61. Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang and Yun Zhao^*. The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. Journal of Biological Chemistry. 2014, 289(32):22333-22341. ?
62. Cuicui Chen, Zhubing Shi, Wenqing Zhang, Min Chen, Feng He, Zhenzhen Zhang, Yicui Wang, Miao Feng, Wenjia Wang, Yun Zhao, Jerry H. Brown, Shi Jiao and Zhaocai Zhou. Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. Journal of Biological Chemistry. 2014, 289(14):9651-9561
63. Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin, Ji, Lei Zhang and Zhaocai Zhou. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014, 25(2):166-180.
64. Hongling Huang, Jinhui Li, Lianxin Hu, Ling Ge, Hongbin Ji, Yun Zhao^* and Lei Zhang^*. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Developmental Biology. 2014, 385(2):211-219. ?
65. Zuoyun Wang, Yihua Sun, Bin Gao, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-yuan Liu, William Pao, Yun Zhao^*, Haiquan Chen^* and Hongbin Ji^*. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters. 2014, 342(1):36-42.
66. Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wenqing Wu, Zhaocai Zhou, Feng Liu, Lei Zhang^* and Yun Zhao^*. Atrophin/Rpd3 complex represses Hedgehog signaling by acting as a co-repressor of Ci^R. Journal of Cell Biology. 2013, 203(4):575-583.
67. Zhao Zhang, Xiangdong Lv, Wen Chi Yin, Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang^* and Yun Zhao^*. Ter94 ATPase complex targets K11-linked ubiquitinated Ci to proteasomes for partial degradation. Developmental Cell. 2013, 25(6):636-644. ?
68. Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao^* and Dahua Chen^*. Activation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover. PLoS Biology. 2013, 11(11):e1001721.
69. Yan Zhang, Lin Fu, Xiaolong Qi, Zhenyi Zhang, Yuanxin Xia, Jianhang Jia, Jin Jiang, Yun Zhao^* and Geng Wu^*. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communications. 2013, 4:2608. ?
70. Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S Ho, Hongbin Ji, Yun Zhao^* and Lei Zhang^*. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. eLIFE. 2013, 2:e00999. ?
71. Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wenqing Wu, Zhaocai Zhou, Lei Zhang^* and Yun Zhao^*. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of Cell Science. 2013, 126(18):4230-4238.
72. Tong Guo, Yi Lu, Peixue Li, Mengxin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao^* and Lei Zhang^*. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research. 2013, 23(10):1201-1214.?
73. Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao^*, Xin-Yuan Liu^* and Lei Zhang^*. Par-1 regulates tissue growth by influencing Hippo phosphorylation status and Hippo-Salvador association. PLoS Biology. 2013, 11(8):e1001620. ?
74. Zhao Zhang, Chenyu Pan and Yun Zhao^*. Hedgehog in the Drosophila testis niche: what does it do there? Protein and Cell. 2013, 4(9):650-655. (invited review) ?
75. Xiangdong Lv, Lin Fu and Yun Zhao^*. aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC. Acta Biochimica et Biophysica Sinica. 2013, 45(7):610-611. (invited review) ?
76. Min Luo,?Te Ling,?Wenbing Xie,?He Sun,?Yonggang Zhou,?Qiaoyun Zhu,?Meili Shen,?Le Zong,?Guoliang Lyu,?Yun Zhao, Tao Ye,?Jun Gu,?Wei Tao,?Zhigang Lu and Ingrid Grummt. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 2013, 31(7):1278-1286.?
77. Dawei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang^* and Yun Zhao^*. Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction.?Journal of Biological Chemistry. 2013,?288:12605-12614.?
78. Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang^* and Yun Zhao^*. Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis.?Cell Research. 2013, 23:573-576. ?
79. Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao^* and Zhaocai Zhou^*. Structure of the MST4 in complex with MO25 provides insights into its activation mechanism.?Structure. 2013, 21:449-461.
80. Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guogang Liu, Cuicui Chen, Miao Feng, Qian Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang and Zhaocai Zhou. Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure. 2013, 21:680-688.
81. Wenjia Wang, Zhubing Shi, Shi Jiao, Cuicui Chen, Huizhen Wang, Guoguang Liu, Qiang Wang, Yun Zhao, Mark I Greene and Zhaocai Zhou. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Research. 2012, 22:1440-1452.
82. Shuo Shi, Yue-Zhen Deng, Jiang-Sha Zhao, Xiao-Dan Ji, Jun Shi, Yu-Xiong Feng, Guo Li, Jing-Jing Li, Di Zhu, H. Phillip Koeffler, Yun Zhao and Dong Xie. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. Journal of Biological Chemistry. 2012, 287(11):7845-7858.
83. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao^* and Lei Zhang^*. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control.?Journal of Biological Chemistry.?2012, 287:5784-5796. ?
84. Yanyan Zhang, Feifei Mao, Yi Lu, Wenqing Wu, Lei Zhang^* and Yun Zhao^*. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.?Cell Research. 2011, 21:1436-1451.
85. Yongbin Chen, Shuang Li, Chao Tong, Yun Zhao, Bing Wang, Yajuan Liu, Jianhang Jia and Jin Jiang. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes and Development. 2010, 24(18):2054-2067.
86. Jun Yang, Xiaoqing Liu, Yun Zhao, Michael Adamian, Basil Pawlyk, Xun Sun, D. Randy McMillan, M. Charles Liberman and Tiansen Li. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genetics. 2010, 6(5):e1000955.
87. Joel M. Hyman, Ari J. Firestone, Vivi M. Heine, Yun Zhao, Cory A. Ocasio, Kyuho Han, Mark Sun, Paul G. Rack, Surajit Sinha, Jason J. Wu, David E. Solow-Cordero, Jin Jiang, David H. Rowitch and James K. Chen. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences USA. 2009, 106(33):14132-14137.
88. Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao, Joel Hyman, Jin Jiang, James K. Chen, Zhen Yang and Shuo Lin. Converse conformational control of smoothened activity by structurally related small molecules. Journal of Biological Chemistry. 2009, 284(31):20876-20884.
89. Yun Zhao, Chao Tong and Jin Jiang. Transducing the Hedgehog signal across the plasma membrane.?Fly. 2007, 1(6):333-336. (invited review)
90. Yun Zhao, Chao Tong and Jin Jiang. Hedgehog regulates Smoothened activity by inducing a conformational switch. Nature. 2007, 450:252-258. (Research Article)
91. Jun Yang, Basil Pawlyk, Xiaohong Wen, Michael Adamian, Maria Soloviev, Norman Michaud,?Yun Zhao, Michael A. Sandberg, Clint L. Makino and Tiansen Li. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals.?Human Molecular Genetics. 2007, 16(9):1017-1029.
92. Xiaoqing Liu,?Yun Zhao, Basil Pawlyk, Margot Damaser and Tiansen Li. Failure of elastic fiber homeostasis leads to pelvic floor disorders.?American Journal of Pathology. 2006, 168(2):519-528.
93. Wensheng Zhang*,?Yun Zhao*, Chao Tong, Gelin Wang, Bing Wang, Jianhang Jia and Jin Jiang. Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.?Developmental Cell. 2005, 8(2):267-278. (*equal contribution).
94. Xiaoqing Liu,?Yun Zhao, Jiangang Gao, Basil Pawlyk, Barry Starcher, Jeffrey A Spencer, Hiromi Yanagisawa, Jian Zuo and Tiansen Li. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.?Nature Genetics. 2004, 36(2):178-182.
95. Yun Zhao, Dong-Hyun Hong, Basil Pawlyk, Guohua Yue, Michael Adamian, Marcin Grynberg, Adam Godzik and Tiansen Li. The retinitis pigmentosa GTPase Regulator (RPGR)-interacting protein: subserving RPGR function and participating in disk morphogenesis.?Proceedings of the National Academy of Sciences USA. 2003, 100(7):3965-3970.
96. Yun Zhao, Zhigang Lu, Min Wu, Qingqing Han, Wei Tao and Zhonghe Zhai. Effect of phosphocreatine on apoptosis induced in Xenopus cell-free system.?Journal of Biological Chemistry. 2001, 276:34573-34578.
97. Yun Zhao, Min Wu, Yan Shen and Zhonghe Zhai. Analysis of nuclear apoptotic process in a cell-free system. Cellular and Molecular Life Science. 2001, 58:298-306.
98. Yun Zhao, Yan Shen, Min Wu and Zhonghe Zhai. The change of nuclear matrix lamina in apoptosis of nucleus. J Chinese Electronic Microscope. 2001, 20(2):87-92.
99. Min Wu, Yun Zhao and Zhonghe Zhai. The ultrastructural observation of apoptotic mouse liver cell nuclei. Journal of Chinese Electronic Microscope. 2001, 20(1):21-26.
100. Yun Zhao, Xiaoling Liu, Min Wu, Wei Tao and Zhonghe Zhai. In vitro nuclear reconstitution could be induced in a plant cell-free system.?FEBS Letters. 2000, 480:208-212.
101. Zhengfan Jiang,?Yun Zhao, Xia Hong and Zhonghe Zhai. Nuclear apoptosis induced by isolated mitochondria.?Cell Research. 2000, 10:221-232.
102. Yun Zhao, Zhengfan Jiang, Yingli Sun and Zhonghe Zhai. Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells.?FEBS Letters. 1999, 448:197-200.
103. Yun Zhao, Yingli Sun, Zhengfan Jiang and Zhonghe Zhai. Apoptosis of carrot nuclei in in vitro system induced by cytochrome c.?Chinese Scince Bulletin. 1999, 44:1497-1501.
104. Yingli Sun,?Yun Zhao, Xia Hong and Zhonghe Zhai. Cytochrome c release and caspase activation during menadione-induced apoptosis in plants.?FEBS Letters. 1999, 462:317-321.
105. Yingli Sun, Yun Zhao, Chunxiang Liu and Zhonghe Zhai. Cytochrome c can induce programmed cell death in plant cells. Acta Botanica Sinica. 1999, 41:379-383.
106. Yingli Sun, Yun Zhao, Jian Wang and Zhonghe Zhai. Distribution of NuMA-like proteins and its changes during cell-cycle in plant cells. Acta Botanica Sinica. 1999, 41:235-240.
107. Danying Chen, Yun Zhao, Dazhong Zhao and Zhonghe Zhai. Study of intermediate filaments in Adiantum philippense and comparative analysis of karetin-like proteins in some plant species. Acta Botanica Sinica. 1998, 40:790-795.