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首頁(yè) 全所PI名錄
  • 王恩多
  • 研究員，中科院院士，博士生導(dǎo)師
  • E-mail: edwang@@sibcb.ac.cn
  • 實(shí)驗(yàn)室主頁(yè): 
    個(gè)人簡(jiǎn)介：

  • 　　1965-1969和1978-1981兩次中國(guó)科學(xué)院上海生物化學(xué)研究所研究生畢業(yè)。1986年任生化所副研究員，1993年任研究員，博士生導(dǎo)師。長(zhǎng)期以氨基酰-tRNA合成酶及其相關(guān)tRNA為對(duì)象研究酶與核酸的相互作用，以期加深人們對(duì)蛋白質(zhì)生物合成質(zhì)量控制機(jī)理的理解。曾獲得國(guó)家自然科學(xué)二等獎(jiǎng)，上海市自然科學(xué)一等獎(jiǎng)、二等獎(jiǎng)，何梁何利科技進(jìn)步獎(jiǎng)，七次中國(guó)科學(xué)院研究生導(dǎo)師獎(jiǎng)，為全國(guó)勞動(dòng)模范?！渡茖W(xué)》和《生命的化學(xué)》副主編,《生物化學(xué)與生物物理學(xué)報(bào)》、《中國(guó)生物化學(xué)與分子生物學(xué)雜志》。EMBO J、Nucleic Acids Research、J. Biol. Chem.和Scientific Reports等雜志的審稿人。為中國(guó)科學(xué)院院士(2005年)、第三世界科學(xué)院(TWAS)院士(2006年)和中國(guó)醫(yī)學(xué)科學(xué)院學(xué)部委員(2019年)。

    社會(huì)任職：
  •  
    研究方向：
  • 　　核酸與酶的相互作用
    研究工作：

  • 　　長(zhǎng)期從事生物化學(xué)與分子生物學(xué)研究。目前主要以tRNA和相關(guān)氨基酰-tRNA合成酶為對(duì)象核酸與酶的相互作用研究。氨基酰-tRNA合成酶是蛋白質(zhì)生物合成過(guò)程中的關(guān)鍵酶，它催化蛋白質(zhì)生物合成過(guò)程中的第一步反應(yīng)-tRNA氨基?；磻?yīng)。氨基酰-tRNA合成酶對(duì)tRNA的精確識(shí)別保證了遺傳信息由核酸傳遞到蛋白質(zhì)的精確性，所以研究tRNA與氨基酰-tRNA合成酶的相互作用具有重要的生物學(xué)意義。隨著研究的深入，該項(xiàng)研究還可以為人類的疾病防止和治療、改善人類生存環(huán)境提供理論依據(jù)和新的思路。

    　　研究組已發(fā)表研究論文120余篇。研究結(jié)果2400余次被包括《生物化學(xué)年鑒》和《細(xì)胞》中的綜述，《美國(guó)科學(xué)院院報(bào)》，《歐洲分子生物學(xué)組織雜志》和《分子細(xì)胞》等學(xué)術(shù)刊物的研究論文引用。研究組與法國(guó)，加拿大，美國(guó)等多家實(shí)驗(yàn)室有合作研究關(guān)系。

    承擔(dān)科研項(xiàng)目情況：
    代表論著：
    1. Peng GX, Zhang Y, Wang QQ, Li QR, Xu H, En-Duo Wang* and Zhou XL*. The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases，Nucleic Acids Research, 2021, 49(5), 2816–2834.
    2. Hao GY, Li H, Yang F, Dong DL, Li ZZ, Ding YY, Pan W, En-Duo Wang*, Liu RJ*, Zhou HC*(2021) Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors，Bioorg. Med. Chem., 2021, 29, 115871.
    3. Li G，Eriani G, En-Duo Wang* and Zhou XL* . Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher -like disease, Sci China Life Sciences, 2021, DOI: 10.1007/s11427-020 -1838-2
    4. Wang Y, Zhou JB, QY Zeng, Wu SQ, Xue MQ, Fang PF, En-Duo Wang* and Zhou XL*. Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNALys, Sci China Life Sciences, 2020, 63, (8), 1227–1239.
    5. Zhou JB, Wang Y, Zeng QY, Meng SX, En-Duo Wang* and Zhou XL*.  Molecular basis for t6A modification in human mitochondria, Nucleic Acids Research, 2020, 48 (6), 3181-3194.
    6. Li J, Wang YN, Xu BS, Liu YP, Chen P, Zhou M, Long T, Li H, Dong H, Nie Y, En-Duo Wang*, Liu RJ*. Intellectual disability associated gene ftsj1 is responsible for 2'-O-methylation of nucleotides at the anticodon loop of specific tRNAs，2020，EMBO Reports，e50095. 
    7. Liu RJ*, Long T, Li H, Zhao JH, Li J, Wang MZ, Palenica A, Lin JZ, Cusack S, and En-Duo Wang*. Structural basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond, Nucleic Acids Research, 2020, 48(9), 4946–4959
    8. Zheng WQ, Zhang YY, Yao, Yuzhe Chen YZ, En-Duo Wang*, Chen C*and Zhou XL*. Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, Nucleic Acids Research, 2020, 48(12), 6799-6810
    9. Jia-Yi Fan, Qian Huang, Quan-Quan Ji, En-Duo Wang*. LeuRS can leucylate type I and type II tRNALeus in Streptomyces coelicolor. Nucleic Acids Research, 2019, 47(12), 6369-6385
    10. Jing Li, Hao Li, Tao Long, Han Dong, En-Duo Wang*, Liu RJ*. Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs, Nucleic Acids Research, 2019, 47(4), 2041-2055.
    11. Qi-Yu Zeng, Gui-Xin Peng, Guang Li, Jin-Bo Zhou, Wen-Qiang Zheng, Mei-Qin Xue, En-Duo Wang*, Zhou XL*. The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, Nucleic Acids Research, 2019, 47(6), 3072-3085
    12. Preyesh Stephen, Sheng Ye, Ming Zhou, Jian Song, Rong-Guang Zhang*, En-Duo Wang*, Richard Giegé and Sheng-Xiang Lin*. Structure of Escherichia coli arginyl-tRNA synthetase in complex with tRNAArg: pivotal role of the D-loop, J. Mol. Biol. 2018, 430, 1590-1605.
    13. Yun Chen, Zhi-Rong Ruan, Yong Wang, Qian Huang, Mei-Qin Xue, Xiao-Long Zhou and En-Duo Wang* . A threonyl-tRNA synthetase-like protein has activities of tRNA aminoacylation and editing, Nucleic Acids Research, 2018, 46 (7), 3643-3656.
    14. Yong Wang, Qi-Yu, Zeng, Wen-Qiang, Zheng, Quan-Quan Ji,Xiao-Long Zhou and En-Duo Wang*. A natural non-Watson-Crick base pair in human mitochondrial tRNAThr causes structural and functional susceptibility to local mutations, Nucleic Acids Research, 2018, 46(9), 4662-4676.
    15. Taru Hilander, Xiao-Long Zhou, Svetlana Konovalova, Fu-Ping Zhang, Liliya Euro, Dmitri Chilov, Matti Poutanen, Joseph Chihade, En-Duo Wang* and Henna Tyynismaa*. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, Nucleic Acids Research, 2018, 46(2), 849-860.
    16. Ru-Juan Liu, Tao Long, Jin Li, Hao Li, En-Duo Wang*. Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. Nucleic Acids Research, 2017,45(11), 6684-6697.
    17. Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Cheng-Wu Chi and En-Duo Wang*. Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. Nucleic Acids Research, 2017, 45(12), 7367-7381.
    18. Qing Ye, Quan-Quan Ji, Wei Yan, Fang Yang, En-Duo Wang*. Acetylation of lysine ε-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli. 2017, J. Biol. Chem., 292 (25), 10709-10722.
    19. Tao Long, Jing Li, Hao Li,MiZhou, Xiao-Long Zhou, Ru-Juan Liu, En-Duo Wang*,Sequence-specific and shape-selective RNA recognition by the human RNA m5C methyltransferase NSun6. J. Biol. Chem.,2016, 291(46), 24293-24303.
    20. Xiao-Long Zhou, YunChen, Zhi-Peng Fang, Zhi-Rong Ruan, Yong Wang, Ru-Juan Liu, Mei-QinXue,En-Duo Wang*,Translational quality control by bacterial threonyl-tRNA synthetases. J. Biol. Chem.,2016, 291 (40), 21208 –21221.
    21. Yong Wang,Xiao-Long Zhou, Zhi-Rong Ruan, Ru-Juan Liu, Gilbert Eriani，En-Duo Wang*, A human disease-causing point mutation in mitochondrial threonyl-tRNA synthetase induces both structural andfunctional defects. J. Biol. Chem., 2016, 291(12), 6507-6520.
    22. Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Zhi-Rong Ruan,Xiao-Long Zhou, En-Duo Wang*, C-terminal domain of leucyl-tRNA synthetase from pathogenic Candida albicans recognizes both tRNASer and tRNALeu. J. Biol. Chem.,2016, 291 (7) , 3613-3625.
    23. Ying Yang, Wei Liu , Zhi-Peng Fang , Juan Shi, Feng-Yu Che,Chun-Xia He, Li-Bo Yao, En-Duo Wang*, Yuan-Ming Wu* , A newly Identified missense mutation in FARS2 causes autosomal-Recessive Spastic Paraplegia.Human Mutation,2016, 37 (2),165-169.
    獲獎(jiǎng)及榮譽(yù)：
    研究組成員：