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人才隊(duì)伍

豆曉陽(yáng)
研究員，研究組長(zhǎng)，博士生導(dǎo)師
E-mail: xiaoyang.dou@sibcb.ac.cn
實(shí)驗(yàn)室主頁(yè): https://doulab.sibcb.ac.cn

個(gè)人簡(jiǎn)介：

2011年畢業(yè)于河北經(jīng)貿(mào)大學(xué)； 2018年畢業(yè)于中科院計(jì)算生物學(xué)研究所，獲計(jì)算生物學(xué)博士學(xué)位；2018年12月至2024年6月于芝加哥大學(xué)從事博士后研究；于2024年7月起任中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心 (生物化學(xué)與細(xì)胞生物學(xué)研究所) 研究員，研究組長(zhǎng)，博士生導(dǎo)師。

社會(huì)任職：

研究方向：

RNA修飾與染色質(zhì)調(diào)控、計(jì)算生物學(xué)

研究工作：

非編碼RNA及其化學(xué)修飾是基因調(diào)控網(wǎng)絡(luò)中的核心調(diào)節(jié)因子，它們?cè)赗NA與蛋白質(zhì)、DNA及其他RNA等生物大分子的相互作用中起著關(guān)鍵作用。這種相互作用對(duì)調(diào)節(jié)染色質(zhì)重塑和基因轉(zhuǎn)錄活化至關(guān)重要，從而影響一系列生物學(xué)過(guò)程。通過(guò)結(jié)合表觀轉(zhuǎn)錄組學(xué)、表觀遺傳學(xué)、基因組學(xué)和計(jì)算生物學(xué)等交叉學(xué)科的優(yōu)勢(shì)，采用干濕實(shí)驗(yàn)相結(jié)合的研究方法，我們將：
（1）深入探索非編碼RNA及其化學(xué)修飾在染色質(zhì)重塑和基因轉(zhuǎn)錄活化中的調(diào)控模式、機(jī)制和生物學(xué)功能。
（2）解析非編碼RNA及其化學(xué)修飾在神經(jīng)退行性疾病和癌癥等人類重大疾病中異常代謝的成因與后果，及其在免疫治療中的作用與機(jī)制。
（3）通過(guò)數(shù)據(jù)整合和深度數(shù)據(jù)挖掘，研究非編碼RNA的命運(yùn)決定模式。
我們的研究目標(biāo)是深化對(duì)具有調(diào)控功能的非編碼RNA及其化學(xué)修飾的理解，拓展其應(yīng)用潛力，為疾病的預(yù)防、診斷和治療提供新的分子靶點(diǎn)和策略。歡迎加入我們！

承擔(dān)科研項(xiàng)目情況：

代表論著：

1. Dou, X.*, Xiao, Y. *, Shen, C. *, Wang, K. *, Wu, T., Liu, C., Li, Y., Yu, X., Liu, J., Dai, Q., Pajdzik, K., Ye, C., Ge, R., Gao, B., Yu, J., Sun, S., Chen, M., Chen, J., & He, C. (2023). RBFOX2 recognizes N⁶-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.?Nature Cell Biology,?25(9), 1359–1368.?
2. Li, Y. *, Dou, X. *, Liu, J. *, Xiao, Y. *, Zhang, Z., Hayes, L., Wu, R., Fu, X., Ye, Y., Yang, B., Ostrow, L. W., He, C., & Sun, S. (2023). Globally reduced N⁶-methyladenosine (m⁶A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration.?Nature Neuroscience,?26(8), 1328–1338.
3. Wang, L.*, Dou, X.*, Chen, S.*, Yu, X., Huang, X., Zhang, L., Chen, Y., Wang, J., Yang, K., Bugno, J., Pitroda, S., Ding, X., Piffko, A., Si, W., Chen, C., Jiang, H., Zhou, B., Chmura, S. J., Luo, C., Liang, H. L., … Weichselbaum, R. R. (2023). YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.?Cancer Cell,?41(7), 1294–1308.e8.
4. Dou, X.*, Huang, L.*, Xiao, Y.*, Liu, C., Li, Y., Zhang, X., Yu, L., Zhao, R., Yang, L., Chen, C., Yu, X., Gao, B., Qi, M., Gao, Y., Shen, B., Sun, S., He, C., & Liu, J. (2023). METTL14 is a chromatin regulator independent of its RNA N⁶-methyladenosine methyltransferase activity.?Protein & Cell,?14(9), 683–697.
5. He, P. C.*, Wei, J.*, Dou, X.*, Harada, B. T., Zhang, Z., Ge, R., Liu, C., Zhang, L. S., Yu, X., Wang, S., Lyu, R., Zou, Z., Chen, M., & He, C. (2023). Exon architecture controls mRNA m⁶A suppression and gene expression.?Science,?379(6633), 677–682.?
6. Liu, J.*, Dou, X.*, Chen, C.*, Chen, C., Liu, C., Xu, M. M., Zhao, S., Shen, B., Gao, Y., Han, D., & He, C. (2020).?N⁶-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.?Science,?367(6477), 580–586.?
7. Dou, X.*, Boyd-Kirkup, J. D.*, McDermott, J.*, Zhang, X.*, Li, F., Rong, B., Zhang, R., Miao, B., Chen, P., Cheng, H., Xue, J., Bennett, D., Wong, J., Lan, F., & Han, J. J. (2019). The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A.?Genome Research,?29(10), 1622–1634.
8. Green, C. D.*, Huang, Y.*, Dou, X.*, Yang, L., Liu, Y., & Han, J. J. (2017). Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors.?Cell Reports,?18(12), 2957–2968.
9. Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., & Guo, S. (2024). Zebrafish Mbd5 binds to RNA m⁵C and regulates histone deubiquitylation and gene expression in development metabolism and behavior.?Nucleic Acids Research, gkae093.?
10. Wu, T., Cheng, A. Y., Zhang, Y., Xu, J., Wu, J., Wen, L., Li, X., Liu, B., Dou, X., Wang, P., Zhang, L., Fei, J., Li, J., Ouyang, Z., & He, C. (2024). KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.?Nature Biotechnology, 10.1038/s41587-023-02109-8.?
11. Xiao, Y., Chen, Y. M., Zou, Z., Ye, C., Dou, X., Wu, J., Liu, C., Liu, S., Yan, H., Wang, P., Zeng, T. B., Liu, Q., Fei, J., Tang, W., & He, C. (2024). Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing.?Nature Methods,?21(2), 247–258.
12. Wang, L., Si, W., Yu, X., Piffko, A., Dou, X., Ding, X., Bugno, J., Yang, K., Wen, C., Zhang, L., Chen, D., Huang, X., Wang, J., Arina, A., Pitroda, S., Chmura, S. J., He, C., Liang, H. L., & Weichselbaum, R. (2023). Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m⁶A/YTHDF2 drives extrinsic radioresistance.?The Journal of Clinical Investigation,?133(24), e172919.
13. Zhang, L., Dou, X., Zheng, Z., Ye, C., Lu, T. X., Liang, H. L., Wang, L., Weichselbaum, R. R., & He, C. (2023). YTHDF2/m⁶?A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs.?The EMBO Journal,?42(15), e113126.
14. Dai, Q., Zhang, L. S., Sun, H. L., Pajdzik, K., Yang, L., Ye, C., Ju, C. W., Liu, S., Wang, Y., Zheng, Z., Zhang, L., Harada, B. T., Dou, X., Irkliyenko, I., Feng, X., Zhang, W., Pan, T., & He, C. (2023). Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution.?Nature Biotechnology,?41(3), 344–354.
15. Chokkalla, A. K., Pajdzik, K., Dou, X., Dai, Q., Mehta, S. L., Arruri, V., & Vemuganti, R. (2023). Dysregulation of the Epitranscriptomic Mark m¹A in Ischemic Stroke.?Translational Stroke Research,?14(6), 806–810.
16. Wei, J., Yu, X., Yang, L., Liu, X., Gao, B., Huang, B., Dou, X., Liu, J., Zou, Z., Cui, X. L., Zhang, L. S., Zhao, X., Liu, Q., He, P. C., Sepich-Poore, C., Zhong, N., Liu, W., Li, Y., Kou, X., Zhao, Y., … He, C. (2022). FTO mediates LINE1 m⁶A demethylation and chromatin regulation in mESCs and mouse development.?Science,?376(6596), 968–973.
17. Chen, C., Liu, W., Guo, J., Liu, Y., Liu, X., Liu, J., Dou, X., Le, R., Huang, Y., Li, C., Yang, L., Kou, X., Zhao, Y., Wu, Y., Chen, J., Wang, H., Shen, B., Gao, Y., & Gao, S. (2021). Nuclear m⁶A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.?Protein & Cell,?12(6), 455–474.
18. Hao, Z., Wu, T., Cui, X., Zhu, P., Tan, C., Dou, X., Hsu, K. W., Lin, Y. T., Peng, P. H., Zhang, L. S., Gao, Y., Hu, L., Sun, H. L., Zhu, A., Liu, J., Wu, K. J., & He, C. (2020). N⁶-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.?Molecular Cell,?78(3), 382–395.e8.
19. Liu, C., Cui, X., Zhao, B. S., Narkhede, P., Gao, Y., Liu, J., Dou, X., Dai, Q., Zhang, L. S., & He, C. (2020). DNA 5-Methylcytosine-Specific Amplification and Sequencing.?Journal of the American Chemical Society,?142(10), 4539–4543.
20. Cheng, H.*, Dou, X.*, & Han, J. D. (2016). Understanding super-enhancers.?Science China. Life Sciences,?59(3), 277–280.
21. Liu, P., Dou, X., Liu, C., Wang, L., Xing, C., Peng, G., Chen, J., Yu, F., Qiao, Y., Song, L., Wu, Y., Yue, C., Li, J., Han, J. D., Tang, K., & Jing, N. (2015). Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate.?Nature Communications,?6, 6830.

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個(gè)人簡(jiǎn)介：

社會(huì)任職：

研究方向：

研究工作：

承擔(dān)科研項(xiàng)目情況：

代表論著：

獲獎(jiǎng)及榮譽(yù)：

研究組成員：