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首頁 全所PI名錄
  • 范衛(wèi)國
  • 研究員，研究組長，博士生導(dǎo)師
  • E-mail: weiguofan@sibcb.ac.cn
  • 實(shí)驗(yàn)室主頁: 
    個(gè)人簡介：

  • 2011年畢業(yè)于南京農(nóng)業(yè)大學(xué)，獲學(xué)士學(xué)位； 2018年于中國科學(xué)院上海巴斯德研究所（現(xiàn)上海免疫與感染研究所）獲博士學(xué)位；2019年至2024年在斯坦福大學(xué)醫(yī)學(xué)院從事博士后研究；于2024年9月起任中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心(生物化學(xué)與細(xì)胞生物學(xué)研究所)研究員，研究組長，博士生導(dǎo)師。

    社會任職：
    研究方向：
  • 細(xì)胞外基質(zhì)與肝臟疾病
    研究工作：

  • 肝臟是人體重要的代謝和免疫器官，而病毒、酒精和代謝導(dǎo)致的慢性肝病影響著超過4.47億的中國居民。細(xì)胞外基質(zhì)(extracellular matrix, ECM) 的改變是慢性肝病誘發(fā)的肝纖維化、肝硬化和肝癌等多種肝臟疾病的重要表現(xiàn)。細(xì)胞外基質(zhì)是由細(xì)胞分泌并在組織中圍繞在其周圍，多種生物活性分子組成的，動態(tài)變化的組織支架。細(xì)胞外基質(zhì)生化成分和機(jī)械力學(xué)的動態(tài)變化對于確定其周圍細(xì)胞的作用和命運(yùn)至關(guān)重要。

    我們的研究交叉融合了機(jī)械力學(xué)、細(xì)胞生物學(xué)、免疫學(xué)等領(lǐng)域，將利用小鼠模型、3D水凝膠體外培養(yǎng)模型、臨床樣本，結(jié)合原子力顯微鏡和流變儀力學(xué)測量，顯微光學(xué)成像，多組學(xué)、單細(xì)胞及其它高通量測序等研究手段，從細(xì)胞外基質(zhì)的成分和機(jī)械力學(xué)兩個(gè)層面上探索肝臟內(nèi)多種細(xì)胞與微環(huán)境的相互作用，并解析慢性肝病及腫瘤進(jìn)展中的分子機(jī)制，包括(但不限于)以下研究方向：

    1. 探索不同肝臟疾病中細(xì)胞外基質(zhì)的動態(tài)變化及其對疾病進(jìn)展的影響，為肝臟疾病診斷和治療提供新的策略。

    2. 開發(fā)不同機(jī)械力學(xué)特性和成分的3D水凝膠體外培養(yǎng)模型，用于探索肝臟疾病中多種細(xì)胞間的交互作用，為肝臟疾病尋找新的藥物靶點(diǎn)。


    承擔(dān)科研項(xiàng)目情況：
    代表論著：
    1. Fan, W., K. Adebowale, Y. Li, M.Rabbi, L. Vancza, D. Chen, K. Kunimoto, G.Mozes, Y.Li, J. Tao, S.P. Monga, G. Charville, R. Wells, R. Dhanasekaran, T. Kim, O. Chaudhur, Natalie T?r?k#, (2024). "Extracellular Matrix Viscoelasticity Drives Liver Cancer Progression in Pre-Cirrhotic NASH." NATURE, 626, 635–642 (2024).
    2. Fan, W#., Y. Li, K. Kunimoto and N. J. T?r?k (2022). "3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis." JoVE (Journal of Visualized Experiments)(180): e63106.
    3. Li, Y., N. T. Adeniji, W. Fan, K. Kunimoto and N. J. T?r?k (2022). "Non-alcoholic fatty liver disease and liver fibrosis during aging." Aging and Disease 13(4): 1239.
    4. Li, Y., W. Fan, F. Link, S. Wang and S. Dooley (2022). "Transforming growth factor β latency: A mechanism of cytokine storage and signalling regulation in liver homeostasis and disease." JHEP Reports 4(2): 100397.
    5. Fan, W. and N. J. Torok (2021). "Editorial: Noninvasive Fibrosis Biomarkers in Patients With NASH With Diabetes." Hepatology Communications 5(4): 553.
    6. Dehnad, A., W. Fan, J. X. Jiang, S. R. Fish, Y. Li, S. Das, G. Mozes, K. A. Wong, K. A. Olson, G. W. Charville, M. Ali and N. J. Torok (2020). "AGER1 downregulation associates with fibrosis in non-alcoholic steatohepatitis and type 2 diabetes." J Clin Invest 130(8): 4320-4330.
    7. Jiang, J. X., S. R. Fish, A. Tomilov, Y. Li, W. Fan, A. Dehnad, D. Gae, S. Das, G. Mozes, G. W. Charville, J. Ramsey, G. Cortopassi and N. J. Torok (2020). "Nonphagocytic Activation of NOX2 Is Implicated in Progressive Non-alcoholic Steatohepatitis During Aging." Hepatology 72(4): 1204-1218.
    8. Fan, W*., T. Liu*, W. Chen*, S. Hammad, T. Longerich, I. Hausser, Y. Fu, N. Li, Y. He, C. Liu, Y. Zhang, Q. Lian, X. Zhao, C. Yan, L. Li, C. Yi, Z. Ling, L. Ma, X. Zhao, H. Xu, P. Wang, M. Cong, H. You, Z. Liu, Y. Wang, J. Chen, D. Li, L. Hui, S. Dooley, J. Hou, J. Jia and B. Sun (2019). "ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice." Gastroenterology (Cover Story)157(5): 1352-1367 e1313.
    9. Fan, W*., S. Xie*, X. Zhao*, N. Li, C. Chang, L. Li, G. Yu, X. Chi, Y. Pan, J. Niu, J. Zhong and B. Sun (2016). "IFN-lambda4 desensitizes the response to IFN-alpha treatment in chronic hepatitis C through long-term induction of USP18." J Gen Virol 97(9): 2210-2220.
    10. Li, Y., J. X. Jiang, W. Fan, S. R. Fish, S. Das, P. Gupta, G. Mozes, L. Vancza, S. Sarkar, K. Kunimoto, D. Chen, H. Park, D. Clemens, A. Tomilov, G. Cortopassi and N. J. Torok (2023). "Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis." Cell Mol Gastroenterol Hepatol 15(1): 197-211.
    11. Chen, W., S. Chen, C. Yan, Y. Zhang, R. Zhang, M. Chen, S. Zhong, W. Fan, S. Zhu, D. Zhang, X. Lu, J. Zhang, Y. Huang, L. Zhu, X. Li, D. Lv, Y. Fu, H. Iv, Z. Ling, L. Ma, H. Jiang, G. Long, J. Zhu, D. Wu, B. Wu and B. Sun (2022). "Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion." Nature Immunol 23(7): 1021-1030.
    12. Zhang, Y., X. Li, Z. Luo, L. Ma, S. Zhu, Z. Wang, J. Wen, S. Cheng, W. Gu, Q. Lian, X. Zhao, W. Fan, Z. Ling, J. Ye, S. Zheng, D. Li, H. Wang, J. Liu and B. Sun (2020). "ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation." Proc Natl Acad Sci U S A 117(6): 3083-3092.
    13. He, L., W. Gu, M. Wang, X. Chang, X. Sun, Y. Zhang, X. Lin, C. Yan, W. Fan, P. Su, Y. Wang, C. Yi, G. Lin, L. Li, Y. Jiang, J. Lu, C. Dong, H. Wang and B. Sun (2018). "Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production." Proc Natl Acad Sci U S A 115(34): 8621-8626.
    獲獎(jiǎng)及榮譽(yù)：
    研究組成員：