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　　2010年畢業(yè)于哈爾濱工業(yè)大學(xué)，獲學(xué)士學(xué)位;2017年畢業(yè)于中國(guó)科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所，獲博士學(xué)位;2017年于哈佛大學(xué)醫(yī)學(xué)院/波士頓兒童醫(yī)院從事博士后研究(獲CRI Irvington Postdoctoral Fellowship資助);2020年晉升為哈佛大學(xué)醫(yī)學(xué)院講師。2021年4月起擔(dān)任中國(guó)科學(xué)院分子細(xì)胞科學(xué)卓越創(chuàng)新中心(中科院生化細(xì)胞所)研究員、研究組長(zhǎng)、博士生導(dǎo)師。入選國(guó)家科技人才計(jì)劃和上海市浦江人才計(jì)劃。

　　近幾年的突破性科學(xué)發(fā)現(xiàn)揭示了黏連蛋白(cohesin)通過(guò)染色質(zhì)環(huán)擠壓方式(loop extrusion)調(diào)控細(xì)胞核內(nèi)一些生物學(xué)過(guò)程，如促進(jìn)DNA損傷修復(fù)中心的形成，調(diào)控B淋巴細(xì)胞V(D)J重排等。這些發(fā)現(xiàn)表明如何精確調(diào)控染色質(zhì)環(huán)擠壓過(guò)程不僅是對(duì)基因組穩(wěn)定性和抗體多樣化至關(guān)重要，也是非常重要的生物學(xué)問(wèn)題之一。

　　我們實(shí)驗(yàn)室主要以小鼠胚胎發(fā)育及淋巴細(xì)胞發(fā)育過(guò)程為研究?jī)?nèi)容，綜合運(yùn)用發(fā)育生物學(xué)、免疫學(xué)、表觀遺傳學(xué)和三維基因組學(xué)等技術(shù)方法，探索染色質(zhì)三維結(jié)構(gòu)變化與基因表達(dá)調(diào)控的關(guān)系。在未來(lái)幾年，我們將聚焦于(但不局限于)染色質(zhì)環(huán)擠壓模型在生物體發(fā)育與疾病發(fā)生發(fā)展過(guò)程中的調(diào)控機(jī)理，為人類發(fā)育缺陷、自身免疫和淋巴瘤等疾病的防治提供新的理論依據(jù)及治療靶點(diǎn)。

1. Meichen Wang, Hai-Qiang Dai*. Hi-Coatis: Capturing the 3D interplay between transcription and chromatin architecture. Molecular Cell. (2025). https://doi.org/10.1016/j.molcel.2025.11.007
2. Rui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu,* and Hai-Qiang Dai*. HTGTS-TCR-Seq for Profiling of Mouse and Human T-Cell Receptor?α?and?β?Gene Rearrangements and Diversity.?Advanced Science. (2025). ?DOI: 10.1002/advs.202509497.
3. Jiayang Li, Hai-Qiang Dai*. Mesoscale sequence feature modulates AID activity in antibody diversification. Acta Biochimica et Biophysica Sinica. (2023). https://doi.org/10.3724/abbs.2023145.
4. Zhuoyi Liang, Lijuan Zhao, Adam Yongxin Ye, Sherry G Lin, Yiwen Zhang, Chunguang Guo, Hai-Qiang Dai, Zhaoqing Ba, Frederick W. Alt. Contribution of the IGCR1 regulatory element and the 3′Igh CTCF-binding elements to regulation of Igh V(D)J recombination. Proceedings of the National Academy of Sciences. (2023). 120 (26), e2306564120.
5. Sai Luo, Jun Zhang, Alex JB Kreutzberger, Amanda Eaton, Robert J Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S Munir Alam, David C Montefiori, Kevin O Saunders, Ming Tian, Hidde Ploegh, Tom Kirchhausen, Bing Chen, Barton F Haynes, Frederick W. Alt. An Antibody from Single Human V_H-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion. Science Immunology.?(2022). DOI: 10.1126/sciimmunol.add5446.
6. LijunWang, Xiuling You, Dengfeng Ruan, Rui Shao, Hai-Qiang Dai, Weiliang Shen, Guo-Liang Xu, Wanlu Liu, Weiguo Zou. TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes.?Nature Communications.?(2022) 13,?4709. https://doi.org/10.1038/s41467-022-32138-x.
7. Yu Zhang, Xuefei Zhang, Hai-Qiang Dai, Hongli Hu, Frederick W. Alt.?The role of chromatin loop extrusion in antibody diversification.?Nature Reviews Immunology. (2022). https://doi.org/10.1038/s41577-022-00679-3.
8. Hai-Qiang?Dai^#*, Hongli Hu^#, Jiangman Lou, Adam Yongxin Ye, Zhaoqing Ba, Xuefei Zhang, Yiwen Zhang, Lijuan Zhao, Hye Suk Yoon, Aimee M. Chapdelaine-Williams, Nia Kyritsis, Huan Chen,Kerstin Johnson, Sherry Lin, Andrea Conte, Rafael Casellas, Cheng-Sheng Lee*, Frederick W. Alt*. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. (2021) 590, 338–343.
   1. Recommended in Faculty Opinions.
9. Hai-Qiang Dai^#, Zhuoyi Liang^#, Amelia N. Chang^#, Aimee M. Chapdelaine-Williams, Beatriz Alvarado, Alex A. Pollen, Frederick W. Alt, Bjoern Schwer. Direct analysis of brain phenotypes via neural blastocyst complementation. Nature Protocols. (2020) 15 (10), 3154-3181.
10. Zhaoqing Ba, Jiangman Lou, Adam Yongxin Ye, Hai-Qiang Dai, Edward W. Dring, Sherry G. Lin, Suvi Jain, Nia Kyritsis, Kyong-Rim Kieffer-Kwon, Rafael Casellas, Frederick W. Alt. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature. (2020) 586,?305–310.
11. Hai-QiangDai^#*, Hongli Hu^#,JiangmanLou,Adam YongxinYe,Aimee M.Chapdelaine-Williams, NiaKyritsis, YiwenZhang, NicoleManfredonia, RachaelJudson, HuanChen, KerstinJohnson, SherryLin, ZhaoqingBa, AndreaConte, RafaelCasellas, Cheng-Sheng Lee*, Frederick W.Alt*. Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination. bioRxiv.(2020). https://doi.org/10.1101/2020.06.30.181222.
12. Amelia N. Chang^#, Zhuoyi Liang^#, Hai-Qiang Dai^#, Aimee M. Chapdelaine-Williams, Nick Andrews, Roderick T. Bronson, Bjoern Schwer, Frederick W. Alt. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. (2018) 563,126-130.
    1. Highlighted by Nature News & Views.
    2. Recommended in Faculty Opinions.
13. Suvi Jain, Zhaoqing Ba, Yu Zhang, Hai-Qiang Dai, Frederick W. Alt. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. (2018) 174 (1),102-116.
14. Hai-Qiang Dai^#, Bang’an Wang^#, Lu Yang^#, Jiajia Chen^#, Guochun Zhu, Meiling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun, Guoliang Xu. TET-mediated?DNA demethylation controls?gastrulation?by?regulating?Lefty-Nodal?signaling. Nature. (2016) 538, 528-532.
    1. Top 10 Achievements of Chinese Sciences in 2016.
    2. Recommended in Faculty Opinions.
15. Xiao Hu, Lei Zhang, Shiqing Mao, Zheng Li, Jiekai Chen, Runrui Zhang, Haiping Wu, Juan Gao, Fan Guo, Wei Liu, Guifang Xu,?Hai-Qiang Dai, Yujiang Geno Shi, Xianlong Li, Boqiang Hu, Fuchou Tang, Duanqing Pei, Guoliang Xu.?Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.?Cell Stem Cell. (2014) 14, 512-522.?