国产午夜福利视频在线播放一区,伊人久久大香线蕉综合热线,国产一区二区波多野结衣,国产精品丝袜久久久久av,婷婷五月亚洲中文字开心,欧美日韩亚洲综合在线,色综合一区二区三区,国产黄色小视频91在线观看,成人片毛片AAA片免费,久久亚洲AV无码专区成人国产,国产1024香蕉在线观看

　　1991年在上海第二醫(yī)科大學(xué)獲得博士學(xué)位，1994年2月至1999年1月期間，在美國(guó)國(guó)立衛(wèi)生研究院(NIH)從事博士后和高級(jí)訪問學(xué)者研究，1998年入選中科院疫學(xué)專業(yè)。1999年1月至今在中科院上海生物化學(xué)與細(xì)胞生物學(xué)研究所，組建分子免疫室，任課題組組長(zhǎng)，博士生導(dǎo)師。2006年4月至2016年12月，任中國(guó)科學(xué)院上海巴斯德研究所所長(zhǎng)。

　　孫兵研究員長(zhǎng)期從事T輔助細(xì)胞(Th)的分化機(jī)制研究，并探討不同的Th細(xì)胞亞群和ILC2細(xì)胞在炎癥和免疫性疾病中的作用機(jī)制?，F(xiàn)為美國(guó)免疫學(xué)家學(xué)會(huì)會(huì)員(American Association of Immunologists; AAI),中國(guó)免疫學(xué)會(huì)副理事長(zhǎng)。2003年榮獲國(guó)家杰出青年研究基金支持，2012年榮獲“上海市自然科學(xué)二等獎(jiǎng)”和2013年榮獲“國(guó)家自然科學(xué)二等獎(jiǎng)”。

　　1. Allergic Asthma

　　近年來因?yàn)榭諝馕廴?如霧霾等)的原因，哮喘發(fā)病率持續(xù)上升，而現(xiàn)有手段并不能有效控制。研究表明，過敏原可以引起肺粘膜上皮細(xì)胞損傷，通過釋放IL-25, IL-33和TSLP等炎癥性細(xì)胞因子，進(jìn)一步激活I(lǐng)I型淋巴樣免疫細(xì)胞(Innate lymphoid type 2 cells: ILC2)。 ILC2細(xì)胞可以分泌IL-5和IL-13，同時(shí)在過敏原的作用下，可以驅(qū)動(dòng)幼稚CD4+T細(xì)胞分化成Th2細(xì)胞，而最終誘導(dǎo)哮喘疾病。實(shí)驗(yàn)室長(zhǎng)期從事Allergic Asthma疾病分子機(jī)制研究，目前重點(diǎn)聚焦Th2和ILC2這兩種免疫細(xì)胞的功能研究及相互作用的調(diào)控機(jī)制。利用過敏性哮喘小鼠模型，結(jié)合哮喘病人的臨床數(shù)據(jù)，研究新的轉(zhuǎn)錄調(diào)控因子、表觀遺傳分子和代謝信號(hào)通路及產(chǎn)物如何調(diào)節(jié)這些細(xì)胞的功能及它們對(duì)哮喘致病進(jìn)程的調(diào)控作用機(jī)制，為開發(fā)新藥和防治哮喘性疾病提供新思想和新策略。

　　2. Cancer Immunotherapy

　　自2011年開始，多種免疫檢查點(diǎn)阻斷劑和靶向免疫細(xì)胞藥物在多種腫瘤治療中取得了良好的臨床效果，已經(jīng)發(fā)展成為目前公認(rèn)的最具潛力的癌癥治療策略。已上市的免疫治療方法，只在部分病人中展現(xiàn)出良好的效果，而在大部分腫瘤患者中出現(xiàn)耐藥性和預(yù)后差等現(xiàn)象，使腫瘤免疫治療具有一定的局限性。本研究依托成熟的小鼠實(shí)驗(yàn)系統(tǒng)和臨床醫(yī)院提供的病人樣本，重點(diǎn)探究Lung Cancer形成過程中CD8+及Treg細(xì)胞的重要調(diào)控作用，并遴選特異性靶標(biāo)，運(yùn)用實(shí)驗(yàn)室完善的單細(xì)胞技術(shù)制備抗體和藥物研發(fā)技術(shù)體系，制備靶向腫瘤Treg和提升CD8+細(xì)胞功能，進(jìn)而開發(fā)有抗腫瘤作用的新型抗體，在體內(nèi)和體外評(píng)價(jià)新抗體的抗腫瘤效果，開發(fā)新藥為針對(duì)Lung Cancer的抗體免疫治療提供新方案和新策略。

　　3. Antibody drug discovery

　　實(shí)驗(yàn)室有近20年抗體研究歷史，已有完備抗體研究相關(guān)平臺(tái)。實(shí)驗(yàn)室已建立了完善的single-cell RT-PCR 制備全人單克隆抗體技術(shù)，尤其針對(duì)感染性疾病，能夠快速獲得有治療性作用的抗體候選藥物。同時(shí)，針對(duì)一些抗原免疫小鼠產(chǎn)生免疫耐受，無法獲得單克隆抗體的問題，利用兔的免疫細(xì)胞具有體細(xì)胞高頻突變和體細(xì)胞基因置換兩種機(jī)制，可以打破免疫耐受。實(shí)驗(yàn)室建立了基于single-cell RT-PCR 制備兔單克隆抗體技術(shù)。我們的技術(shù)體系涵蓋靶點(diǎn)發(fā)現(xiàn)與驗(yàn)證，抗體制備和功能評(píng)估以及知識(shí)產(chǎn)權(quán)管理等抗體藥物研發(fā)的關(guān)鍵步驟。實(shí)驗(yàn)室已成功研發(fā)并轉(zhuǎn)化了HCV廣譜中和全人抗體等項(xiàng)目。目前實(shí)驗(yàn)室正聚焦哮喘及腫瘤等疾病。開展基礎(chǔ)和臨床研究，研發(fā)創(chuàng)新的抗體藥物。

1. Chen W, Chen S, Yan C, Zhang Y, Zhang R, Chen M, Zhong S, Fan W, Zhu S, Zhang D, Lu X, Zhang J, Huang Y, Zhu L, Li X, Lv D, Fu Y, Iv H, Ling Z, Ma L, Jiang H, Long G, Zhu J, Wu D, Wu B, Sun B. Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. Nat Immunol. 2022 Jul;23(7):1021-1030.
2. Sun X, Yi C, Zhu Y, Ding L, Xia S, Chen X, Liu M, Gu C, Lu X, Fu Y, Chen S, Zhang T, Zhang Y, Yang Z, Ma L, Gu W, Hu G, Du S, Yan R, Fu W, Yuan S, Qiu C, Zhao C, Zhang X, He Y, Qu A, Zhou X, Li X, Wong G, Deng Q, Zhou Q, Lu H, Ling Z, Ding J, Lu L, Xu J, Xie Y, Sun B. Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. Nat Microbiol. 2022 Jul;7(7):1063-1074.
3. Sun X, Liu C, Lu X, Ling Z, Yi C, Zhang Z, Li Z, Jin M, Wang W, Tang S, Wang F, Wang F, Wangmo S, Chen S, Li L, Ma L, Zhang Y, Yang Z, Dong X, Qian Z, Ding J, Wang D, Cong Y, Sun B. Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus. Nat Commun. 2022 May 2;13(1):2378.
4. Yi C, Sun X, Lin Y, Gu C, Ding L, Lu X, Yang Z, Zhang Y, Ma L, Gu W, Qu A, Zhou X, Li X, Xu J, Ling Z, Xie Y, Lu H, Sun B. Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants. Genome Med. 2021 Oct 14;13(1):164. doi: 10.1186/s13073-021-00985-w.
5. Chunyan Yi, Xiaoyu Sun , Jing Ye, Longfei Ding , Meiqin Liu , Zhuo Yang , Xiao Lu , Yaguang Zhang? , Liyan Ma , Wangpeng Gu , Aidong Qu , Jianqing Xu , Zhengli Shi *, Zhiyang Ling* and Bing Sun*;Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cellular & Molecular Immunology ,2020,17:621–630.
6. Yaguang Zhang, Xuezhen Li, Zhongguang Luo, Liyan Ma, Songling Zhu, Zhishuo Wang, Jing Wen, Shipeng Cheng, Wangpeng Gu, Qiaoshi Lian, Xinhao Zhao, Weiguo Fan, Zhiyang Ling, Jing Ye, Songguo Zheng, Dangsheng Li, Hongyan Wang, Jie Liu*, Bing Sun*; ECM1 is an essential factor for the determination of M1macrophage polarization in IBD in response to LPS stimulation, PNAS, 2020, 117(6): 3083-3092.
7. Weiguo Fan, Tianhui Liu, Wen Chen, Seddik Hammad, Thomas Longerich,Ingrid Hausser, Yadong Fu, Nan Li, Yajing He, Cui Liu, Yaguang Zhang, Qiaoshi Lian, Xinhao Zhao, Chenghua Yan, Li Li, Chunyan Yi, Zhiyang Ling, Liyan Ma, Xinyan Zhao, Hufeng Xu, Ping Wang, Min Cong, Hong You, Zhihong Liu, Yan Wang, Jianfeng Chen, Dangsheng Li, Lijian Hui, Steven Dooley*, Jinlin Hou*, Jidong Jia* and Bing Sun* (2019). ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice. Gastroenterology. 2019;157:1352–1367.
8. Lan He , Wangpeng Gu , Meng Wang , Xiaoyan Chang , Xiaoyu Sun , Yuan Zhang , Xuan Lin , Chenghua Yan , Weiguo Fan , Pan Su , Yanming Wang , Chunyan Yi , Guomei Lin , Li Li , Yu Jiang , Junxia Lu , Chen Dong , Haikun Wang , Bing Sun*. Extracellular Matrix Protein 1 promotes follicular helper T cells differentiation and antibody production. PNAS, 2018,115(34)：8621-8626.
9. Qiaoshi Lian, Jun Xu, Shanshan Yan, Min Huang*, Honghua Ding, Xiaoyu Sun, Aiwei Bi, Jian Ding*, Bing Sun*, Meiyu Geng*, Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research ,2017,27:784-800.
10. Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen,?Jianping Ding?&?Bing Sun*.? Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses.?Nature Communications,?2016;7: 13577
11. Su Pan, Chen Sheng, Zheng Yuhan, Zhou Haiyan, Yan CH, Yu F, Zhang YG, He L, Zhang Y, Wang YM, Wu L, Wu XA, Yu BK, Ma LY, Yang ZR, Wang JH, Zhao GX, Zhu JF, Wu ZY,?Sun B*. Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis.?Journal of Immunology?2016; 197(4): 1054-1064.
12. OuYang Bo, Xie SQ, Berardi MJ, Zhao XH, Dev J, Yu WJ,?Sun B*, Chou JJ*. Unusual architecture of the p7 channel from hepatitis C virus.?Nature?.2013; 498(7455):521.
13. Mao Kairui, Chen SZ, Chen MK, Ma YL, Wang Y, Huang B, He ZY, Zeng Y, Hu Y, Sun SH, Li J, Wu XD, Wang XR, Strober W, Chen C, MengGX,?Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.?Cell Research?.2013; 23(2):201-212.
14. Zhenhu Li,Yuan Zhang, Zhiduo Liu, Xiaodong Wu, Yuhan Zheng, Zhiyun Tao， Kairui Mao, Jie Wang, Guomei Lin, Lin Tian, Yongyong Ji, Meiling Qin, Shuhui Sun, Xueliang Zhu, and?Bing Sun*. Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1.?Nature Immunology.?2011; 12(2):178-85
15. Zhiduo Liu, Zhenhu Li, Kairui Mao, Jia Zou, Yuan Wang, Zhiyun Tao, Guomei Lin, Lin Tian, Yongyong Ji, Xiaodong Wu, Xueliang Zhu, Shuhui Sun, Weiguang Chen, Charlie Xiang and?Bing Sun*. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.?Journal of Immunology. 2009; 183(10):6320-9
16. Xuexian O Yang, Pornpimon Angkasekwinai, Jinfang Zhu, Juan Peng, Zhiduo Liu, Roza Nurieva, Xikui Liu, Yeonseok Chung, Seon Hee Chang,?Bing Sun*, Chen Dong*. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.?Nature Immunology. 2009; 10(12):1260-6
17. Mude Shi, Weiwen Deng, Enguang Bi, Kairui Mao, Yongyong Ji, Guomei Lin, Xiaodong Wu, Zhiyun Tao, Zhenhu Li, Xinfen Cai, Shuhui Sun, Charlie Xiang and?Bing Sun*. TRIM30a negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation.?Nature Immunology. 2008; 9(4):369-77.
18. Wei Lu, Bojian Zheng, Ke Xu, Wolfgang Schwarz, Jiadong Cheng, Shuming Duan, Vincent Deubel,?Bing Sun^*.? SARS-CoV 3a protein forms an ion channel and modulates virus release.?PNAS.?2006; 103(33);12540-12545