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首頁 全所PI名錄
  • 李逸平
  • 研究員，研究組長，博士生導師
  • E-mail: yipingli@@sibcb.ac.cn
  • 實驗室主頁: 
    個人簡介：

  • 李逸平博士自1990年起先后在中國科學院上海細胞生物學研究所、中國科學院上海生物化學與細胞生物學研究所任助理研究員、副研究員、研究員，曾任課題組長、所長助理、副所長等職，并兼任中國細胞生物學會理事、副秘書長。2000年4月起同時擔任上海市科學技術協(xié)會副主席，曾兼任國家人類基因組南方研究中心、國家藥物篩選研究中心、上海市新藥研究開發(fā)中心等理事長。李逸平研究員一直從事細胞生物學和發(fā)育生物學方面的研究工作，以斑馬魚、小鼠為模式動物重點研究生殖細胞及早胚胎發(fā)育調(diào)控機制，主要研究成果以論文、專利形式體現(xiàn)。曾先后參與或主持了國家科技部、國家自然科學基金、中科院、農(nóng)業(yè)部和上海市的科學研究項目。

    社會任職：
    研究方向：
  • 生殖細胞與胚胎發(fā)育的機制研究
    研究工作：

  • 眾所周知，生命個體從受精卵開始經(jīng)過一系列的生物學事件發(fā)育成熟，其中蘊藏著精妙的分子調(diào)控機制，這是科學家們一直以來想要闡明的科學奧秘。本實驗室多年來一直從事胚胎發(fā)育和生殖細胞方面的研究，主要以斑馬魚和小鼠等為研究模型，利用實驗生物學以及生物信息學等手段對早期胚胎發(fā)育過程中母型因子調(diào)控胚胎發(fā)育以及合子型基因開啟的機制等方面進行研究，以闡明早期胚胎發(fā)育的分子調(diào)控機制。同時，我們也建立了斑馬魚胚胎細胞體外培養(yǎng)體系以及基于胚胎細胞移植的斑馬魚半克隆技術，并以此工具研究斑馬魚母型合子型轉換的調(diào)控機制及重編程機制，這不僅能簡化斑馬魚基因編輯品系的建立方法，同時也有助于了解發(fā)育缺陷、不孕不育等疾病的發(fā)病機理。

    承擔科研項目情況：
    代表論著：
    1. Xu J, Liu SQ, Ai YR, Zhang YB, Li SF, Li YP*. Establishment and transcriptome analysis of single blastomere-derived cell lines from zebrafish, J Genet Genomics 2024; 51(9):957-969.
    2. Liu SQ, Xu J, Ai YR, Zhang YB, Li SF, Li JS, Li YP*. Derivation of zebrafish heart-related haploid cells. J Mol Cell Biol 2023; 15(12), mjad077
    3. Zhang XY, Li YP, Zhang YB, Li SF. Characterization of small RNAs in early zebrafish PGCs. Acta Biochim Biophys Sin 2021; 53(4): 514-516.
    4. Yang QY, Li RH, Lyu QF, Hou Li, Liu Z, Sun, Q, Liu M, Shi HJ, Xu BY, Yin MR, Yan ZG, H Y, Liu MF, Li YP*, Wu LG. Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes. Nat Commun 2019;10(1):3389.
    5. Zhang XY, Li XT, Li RH, Zhang YB, Li YP, Li SF. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. PLoS One 2019; 14(8): e0220364.
    6. Zhang WW, Zhang YB, Li SF, Yan YC, Li YP*. Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin. Acta Biochim Biophys Sin 2018;50(12): 1280-1287.
    7. Liu WQ, Li SF, Zhang YB, Li JS, Li YP*. Efficient CRISPR-based genome editing using tandem guide RNAs and editable surrogate reporters. Febs Open Bio 2018; 8(7): 1167-1175.
    8. Liu WQ, Zhang YB, Li SF, Li YP*. Rapid and efficient CRISPR-mediated genome editing with cloning-free method. Acta Biochim Biophys Sin 2018; 50(11): 1173-1175.
    9. Zhao XX, Zhang YB, Ni PL, Wu ZL, Yan YC, Li YP*. Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45a Stress Sensor Gene. J Biol Chem 2016; 291(1): 402-412.
    10. Zhang WW, Zhang YB, Zhao XX, Hua Y, Wu ZL, Yan YC, Li YP* Prmt7 regulates epiboly by facilitating 2-OST and modulating actin cytoskeleton. J Mol Cell Biol 2015; 7(5):489-91
    11. Zheng HP, Du Y, Hua Y, Wu ZL, Yan YC, Li YP*. Essential role of Fbxl14 ubiquitin ligase in regulation of vertebrate axis formation through modulating Mkp3 level. Cell Res 2012;22(5):936–940
    12. Hu SN, Yu H, Zhang YB, Wu ZL, Yan YC, Li YX, Li YY, Li YP*. Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish. FEBS Lett 2012; 586(3):222–228.
    13. Cao JL, Shen YD, Zhu L, Xu YN, Zhou YZ, Wu ZL, Li YP, Yan XM, Zhu XL. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol 2012; 14(7):697-706.
    14. Hu SN, Wu ZL, Yan YC, and Li YP*. Sox31 is involved in central nervous system anteroposterior regionalization through regulating the organizer activity in zebrafish. Acta Biochim Biophys Sin 2011; 43(5):387–399
    15. Zheng HP, Li SF, Wu ZL, Zhang YB, Hu SN, Yan YC, Li YP*. Diferential response of multiple zebra？sh hepatic F-box protein genes to 17α-ethinylestradiol treatment. J Environ Sci 2011; 23(4):664–670
    16. Li SF, Liu HX, Zhang YB, Yan YC, Li YP*. The protective effects of alpha-ketoacids against oxidative stress on rat spermatozoa in vitro. Asian J Androl 2010; 12(2):247-256.
    17. Sun C, Xu M, Xing Z, Wu Z, Li Y, Li T, Zhao M. Expression and function on embryonic development of lissencephaly-1 genes in zebrafish. Acta Biochim Biophys Sin 2009; 41(8): 677-688.
    18. Liu H, Wang Z, Li S, Zhang Y, Yan YC, Li YP*. Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts. Mol Biol Rep 2009; 36(6):1469-1474.
    19. Lv W, Zhang Y, Wu Z, Chu L, Koide SS, Chen Y, Yan Y, Li YP*. Identification of wsb1 gene as an important regulator in the development of zebrafish embryo during midblastula transition. Acta Biochim Biophys Sin 2008; 40(6):478-488.
    20. Li S, Zhang Y, Liu H, Yan Y, Li YP*. Identification and expression of gabac receptor in rat testis and spermatozoa. Acta Biochim Biophys Sin 2008; 40(8):761-767.
    21. Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L. Nuclear dvl, c-jun, beta-catenin, and tcf form a complex leading to stabilization of beta-catenin-tcf interaction. J Cell Biol 2008; 180 (6):1087-1100.
    22. Ding Y, Xi Y, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L. Caprin-2 enhances canonical wnt signaling through regulating lrp5/6 phosphorylation. J Cell Biol 2008; 182(5):865-872.
    23. Liu QY, Wu ZL, Lv WJ, Yan YC, Li YP*. Developmental expression of cyclin h and cdk7 in zebrafish: The essential role of cyclin h during early embryo development. Cell Res. 2007; 17(2):163-173.
    24. Li SF, Hu JH, Yan YC, Chen YG, Koide SS, Li YP*. Identification and characterization of a novel splice variant of beta3 subunit of gaba(a) receptor in rat testis and spermatozoa. Int J Biochem Cell Biol 2005; 37(2):350-360.
    25. Qiu JJ, Zhang WW, Wu ZL, Wang YH, Qian M, Li YP*. Delay of zga initiation occurred in 2-cell blocked mouse embryos. Cell Res 2003; 13(3):179-185.
    26. He XB, Yan YC, Li YP*, Koide SS. Cloning of rat sp56, the homologue of mouse sperm zp3 receptor-sp56. Cell Res 2003; 13(2):121-129.
    27. He X, Zhang Y, Yan Y, Li YP*, Koide SS. Identification of gababr2 in rat testis and sperm. J Reprod Dev 2003; 49(5):397-402.
    獲獎及榮譽：
    研究組成員：