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1998年本科畢業(yè)于南開大學(xué)，2003年畢業(yè)于中國科學(xué)院上海生命科學(xué)研究院生物化學(xué)與細胞生物學(xué)研究所，獲理學(xué)博士學(xué)位。2003-2012年先后在美國Scripps研究所和哈佛大學(xué)公共衛(wèi)生學(xué)院進行博士后研究并受美國白血病淋巴瘤協(xié)會資助，2009年入選哈佛大學(xué)公共衛(wèi)生學(xué)院Yerby Fellow，2012年獲聘康納爾大學(xué)和紐約州立大學(xué)布法羅分校Tenure Track助理教授職位，2012年8月加入中國科學(xué)院生物化學(xué)與細胞生物學(xué)研究所，任研究員、研究組長、博士生導(dǎo)師。獲國家自然科學(xué)基金委杰出青年科學(xué)基金、優(yōu)秀青年基金，國家海外高層次人才計劃（青年類）資助，主持國家自然科學(xué)基金委重大項目、重點項目，國家重點基礎(chǔ)研究發(fā)展計劃（973計劃）課題，中國科學(xué)院戰(zhàn)略性先導(dǎo)科技專項課題等。擔(dān)任國際華人骨研學(xué)會（ICMRS）董事會董事、中國生物工程學(xué)會轉(zhuǎn)化醫(yī)學(xué)專業(yè)委員會副主任委員、中華醫(yī)學(xué)會骨科學(xué)分會組織工程與再生醫(yī)學(xué)青年組組長、中國骨質(zhì)疏松與骨礦鹽疾病分會基礎(chǔ)組常委、中國老年醫(yī)學(xué)會骨質(zhì)疏松分會創(chuàng)新與轉(zhuǎn)化專委會常委等。

運動系統(tǒng)功能性干細胞包括骨膜干細胞、生長板干細胞、骨髓間充質(zhì)干細胞、關(guān)節(jié)軟骨干細胞、肌腱干細胞、肌肉干細胞等。運動系統(tǒng)功能性干細胞具有多能性和自我更新能力，在組織發(fā)育、穩(wěn)態(tài)維持、疾病和衰老等過程中起重要作用。運動系統(tǒng)功能性干細胞向不同組織細胞的分化受到多種遺傳因素和表觀遺傳因素的影響，并受多種信號途徑調(diào)控。調(diào)控因素的異常將導(dǎo)致多種疾病，包括先天性發(fā)育畸形、運動系統(tǒng)退行性疾病如骨質(zhì)疏松癥、骨性關(guān)節(jié)炎以及肌腱疾病等。

研究組通過綜合運用空間轉(zhuǎn)錄組測序、單細胞測序、譜系示蹤等多種研究手段來鑒定運動系統(tǒng)新型干細胞。已建立了間充質(zhì)干細胞向多種細胞分化的體外高通量篩選系統(tǒng)，研究干細胞增殖分化的分子機制及多種相關(guān)疾病的致病機理，并通過分子遺傳學(xué)手段建立了骨骼早衰、力學(xué)感知失調(diào)、關(guān)鍵干細胞穩(wěn)態(tài)失調(diào)等多種動物模型，模擬骨質(zhì)疏松、骨關(guān)節(jié)炎、骨折等常見骨科疾病，圍繞骨骼系統(tǒng)的受力、衰老與功能性干/前體細胞等關(guān)鍵科學(xué)問題，在骨科基礎(chǔ)研究領(lǐng)域取得了多項創(chuàng)新性研究成果。

實驗室近期研究方向包括：

1）鑒定運動系統(tǒng)功能性干細胞，研究其參與損傷修復(fù)的命運轉(zhuǎn)歸和調(diào)控機制。

2）研究機械力對間充質(zhì)干細胞/運動系統(tǒng)功能性干細胞的調(diào)控及其分子機制。

3）研究間充質(zhì)干細胞/運動系統(tǒng)功能性干細胞的衰老與疾病的關(guān)聯(lián)及分子機制。

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