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　　主要從事形態(tài)發(fā)生基因表達(dá)調(diào)控與表觀遺傳調(diào)控的研究。在基因水平、染色質(zhì)水平和細(xì)胞水平研究白念珠菌形態(tài)發(fā)生的調(diào)控機(jī)制。包括白念珠菌形態(tài)轉(zhuǎn)變和致病相關(guān)因子的鑒定與功能研究，信號(hào)轉(zhuǎn)導(dǎo)途徑在白念珠菌形態(tài)發(fā)生和致病過(guò)程中的調(diào)控機(jī)制，轉(zhuǎn)錄因子、染色質(zhì)修飾復(fù)合物和染色質(zhì)重塑復(fù)合物在白念珠菌菌絲發(fā)育和白灰形態(tài)轉(zhuǎn)換過(guò)程的功能作用,白念珠菌與宿主細(xì)胞的相互作用以及在白念珠菌感染過(guò)程宿主細(xì)胞的免疫應(yīng)答調(diào)控網(wǎng)絡(luò)研究。在學(xué)術(shù)期刊上發(fā)表了60余篇研究論文，獲得授權(quán)發(fā)明專利10多項(xiàng)，申報(bào)發(fā)明專利多項(xiàng)。

1. Minghui Yan, Xinyi Nie, Huafeng Wang, Ning Gao, Haoping Liu and Jiangye Chen*, Sumoylation of Wor1 by a novel SUMO E3 ligase controls cell fate in Candida albicans. Mol Microbiol. 2015 Jun 25. doi: 10.1111.
2. Peng Chang, Xueyi Fan and Jiangye Chen*, Function and subcellular localization of Gcn5, a histone acetyltransferase in Candida albicans. Fungal Genet Biol. 2015 Feb 3. doi: 10.1016.
3. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*, Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6): 642-52.
4. Shicheng Zhang, Tianlong Zhang, Minghui Yan, Jianping Ding* and Jiangye Chen*, Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans. Cell Res. 2014; 24(9):1108-20.
5. Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding* Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. Elife. 2014; 3. doi: 10.7554/eLife.02687.
6. Zhe Zhang, Shanshan Wang, Tong Shen, Jiangye Chen, and Jianping Ding,*Crystal Structure of the Rab9A-RUTBC2 RBD Complex Reveals the Molecular Basis for the Binding Specificity of Rab9A with RUTBC2. Structure. 2014; 22(10): 1408-20.
7. Shan Li, Wei Song, Mei Jiang, Liyong Zeng, Xueliang Zhu, Jiangye Chen*, Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Letters, 2014; 588 (11): 1989-96.
8. Xiongjun Wang, Peng Chang, Jianping Ding and Jiangye Chen*, Distinct and Redundant Roles of the Two MYST Histone Acetyltransferases Esa1 and Sas2 in Cell Growth and Morphogenesis of Candida albicans. Eukaryot. Cell, 2013; 12 (3): 438-449.
9. Wenji Song, HuafengWang and Jiangye Chen*, Candida albicans Sfl2, a temperature-induced transcriptional regulator, is required for virulence in a murine gastrointestinal infection model. FEMS Yeast Res, 2011, 11(2): 209-22.
10. HuafengWang, Wenji Song, Guanghua Huang, Zhou Zhou, Yufeng Ding and Jiangye Chen*, Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state. FEBS Letters, 2011, 585, 797–802.
11. Xinyi Nie, Xiaoyan Liu, HuafengWang and Jiangye Chen*, Deletion of EFG1 promotes Candida albicans opaque formation responding to pH via Rim101. Acta Biochim Biophys Sin, 2010,?42, 735-744.
12. Chang Su, Yandong Li, Yang Lu and Jiangye Chen*, Mss11, a Transcriptional Activator, is Required for Hyphal Development in Candida albicans. Eukaryot. Cell, 2009, 8 (11): 1780-1791.
13. Mei Jiang, Yankun Gao, Tao Yang, Xueliang Zhu, Jiangye Chen*, Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Letters, 2009, 583, 2171–2178.
14. Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu, and Jiangye Chen*. Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans. Mol. Biol. Cell. 2008, 19(10): 4260-4272.
15. Xuming Mao, Yandong Li, Huafeng Wang, Fang Cao, Jiangye Chen*. Antagonistic Interplay of Swi1 and Tup1 on Filamentous Growth of Candida albicans. FEMS Microbiol Lett, 2008, 285: 233-241.
16. Yandong Li, Chang Su, Xuming Mao, Fang Cao, and Jiangye Chen*. Roles of Candida albicans Sfl1 in Hyphal Development. Eukaryot. Cell, 2007, 6: 2112-2121.
17. Xuming Mao, Fang Cao, Xinyi Nie, Haoping Liu, Jiangye Chen*. The Swi/Snf chromatin remodeling complex is essential for hyphal development in Candida albicans. FEBS Letters, 2006, 580, 2615-2622.
18. Yan-kun Gao, Mei Jiang, Tao Yang, Jiangye Chen*. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. Cell Res., 2006, 16, 539-547.
19. Fang Cao, Shelley Lane, Prashna Pala Raniga, Yang Lu, Zhou Zhou, Karalyn Ramon, Jiangye Chen*, Haoping Liu*. The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans. Mol Biol Cell. 2006; 17(1):295-307.
20. Guanghua Huang, Huafeng Wang, Song Chou, Xinyi Nie, Jiangye Chen*, and Haoping Liu*. Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans. Proc Natl Acad Sci USA. 2006, 103, 12813-12818.

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