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　　1991年在上海第二醫(yī)科大學(xué)獲得博士學(xué)位，1994年2月至1999年1月期間，在美國國立衛(wèi)生研究院(NIH)從事博士后和高級訪問學(xué)者研究，1999年1月至今在中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所，組建分子免疫室，任課題組組長，博士生導(dǎo)師。2006年4月至2016年12月，任中國科學(xué)院上海巴斯德研究所所長。

　　孫兵研究員長期從事T輔助細(xì)胞(Th)的分化機(jī)制研究，并探討不同的Th細(xì)胞亞群在自身免疫病中的作用機(jī)制研究?，F(xiàn)為美國免疫學(xué)家學(xué)會(huì)會(huì)員(American Association of Immunologists; AAI)，中國免疫學(xué)會(huì)副理事長，中國細(xì)胞學(xué)會(huì)常務(wù)理事。2003年榮獲國家杰出青年研究基金支持，2012年榮獲“上海市自然科學(xué)二等獎(jiǎng)”和2013年榮獲“國家自然科學(xué)二等獎(jiǎng)”。

　　1. Allergic Asthma

　　近年來因?yàn)榭諝馕廴?如霧霾等)的原因，哮喘發(fā)病率持續(xù)上升，而現(xiàn)有手段并不能有效控制。研究表明，過敏原可以引起肺粘膜上皮細(xì)胞損傷，通過釋放IL-25, IL-33和TSLP等炎癥性細(xì)胞因子，進(jìn)一步激活I(lǐng)I型淋巴樣免疫細(xì)胞(Innate lymphoid type 2 cells: ILC2)。 ILC2細(xì)胞可以分泌IL-5和IL-13，同時(shí)在過敏原的作用下，可以驅(qū)動(dòng)幼稚CD4+T細(xì)胞分化成Th2細(xì)胞，而最終誘導(dǎo)哮喘疾病。實(shí)驗(yàn)室長期從事Allergic Asthma疾病分子機(jī)制研究，目前重點(diǎn)聚焦Th2和ILC2這兩種免疫細(xì)胞的功能研究及相互作用的調(diào)控機(jī)制。利用過敏性哮喘小鼠模型，結(jié)合哮喘病人的臨床數(shù)據(jù)，研究

新的轉(zhuǎn)錄調(diào)控因子、表觀遺傳分子和代謝信號通路及產(chǎn)物如何調(diào)節(jié)這些細(xì)胞的功能及它們對哮喘致病進(jìn)程的調(diào)控作用機(jī)制，為開發(fā)新藥和防治哮喘性疾病提供新思想和新策略。

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　　2. Cancer Immunotherapy

　　自2011年開始，多種免疫檢查點(diǎn)阻斷劑和靶向免疫細(xì)胞藥物在多種腫瘤治療中取得了良好的臨床效果，已經(jīng)發(fā)展成為目前公認(rèn)的最具潛力的癌癥治療策略。已上市的免疫治療方法，只在部分病人中展現(xiàn)出良好的效果，而在大部分腫瘤患者中出現(xiàn)耐藥性和預(yù)后差等現(xiàn)象，使腫瘤免疫治療具有一定的局限性。本研究依托成熟的小鼠實(shí)驗(yàn)系統(tǒng)和臨床醫(yī)院提供的病人樣本，重點(diǎn)探究Lung Cancer形成過程中CD8+及Treg細(xì)胞的重要調(diào)控作用，并遴選特異性靶標(biāo)，

運(yùn)用實(shí)驗(yàn)室完善的單細(xì)胞技術(shù)制備抗體和藥物研發(fā)技術(shù)體系，制備靶向腫瘤Treg和提升CD8+細(xì)胞功能，進(jìn)而開發(fā)有抗腫瘤作用的新型抗體，在體內(nèi)和體外評價(jià)新抗體的抗腫瘤效果，開發(fā)新藥為針對Lung Cancer的抗體免疫治療提供新方案和新策略。

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　　3. Antibody drug discovery

　　實(shí)驗(yàn)室有近20年抗體研究歷史，已有完備抗體研究相關(guān)平臺(tái)。實(shí)驗(yàn)室已建立了完善的single-cell RT-PCR 制備全人單克隆抗體技術(shù)，尤其針對感染性疾病，能夠快速獲得有治療性作用的抗體候選藥物。同時(shí)，針對一些抗原免疫小鼠產(chǎn)生免疫耐受，無法獲得單克隆抗體的問題，利用兔的免疫細(xì)胞具有體細(xì)胞高頻突變和體細(xì)胞基因置換兩種機(jī)制，可以打破免疫耐受。實(shí)驗(yàn)室建立了基于single-cell RT-PCR 制備兔單克隆抗體技術(shù)。我們的技術(shù)體系涵蓋靶點(diǎn)發(fā)現(xiàn)與驗(yàn)證，抗體制備和功能評估以及知識(shí)產(chǎn)權(quán)管理等抗體藥物研發(fā)的關(guān)鍵步驟。實(shí)驗(yàn)室已成功研發(fā)并轉(zhuǎn)化了HCV廣譜中和全人抗體等項(xiàng)目。目前實(shí)驗(yàn)室正聚焦哮喘及腫瘤等疾病。開展基礎(chǔ)和臨床研究，研發(fā)創(chuàng)新的抗體藥物。

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