国产大片91精品免费观看3,精品国产99久久久久久,18禁精品久久久国产精品久,玖玖玖国产精品一区二区,亚洲五月婷婷综合网,亚洲中文av字幕在线观看</title>

　　1985年畢業(yè)于第四軍醫(yī)大學空軍醫(yī)學系，1988年在該校獲碩士學位。1993年在瑞典卡羅琳斯卡醫(yī)學院神經(jīng)科學系進修一年。1996年任第四軍醫(yī)大學空軍醫(yī)學系副教授，1999年獲醫(yī)學博士學位。1999年11月在中國科學院神經(jīng)科學研究所感覺系統(tǒng)研究組任副研究員，2002年10月獲中科院上海生命科學研究院“優(yōu)秀青年人才計劃”，同年任合作課題組長。獲2003年度國家自然科學杰出青年基金資助。2004年4月任中科院生化與細胞所課題組長、研究員、博士生導師，現(xiàn)任中科院分子細胞科學卓越創(chuàng)新中心課題組長、研究員、博士生導師。承擔國家自然科學基金重點項目和國家重大研究計劃項目，獲得軍隊科技進步一等獎、二等獎各1次、國家科技進步三等獎1次、上海市科學技術進步二等獎1次。獲上海市“三八”紅旗手榮譽稱號、上海市志愿服務先進集體?，F(xiàn)兼任上海市女科學家聯(lián)誼會副理事長、上海市創(chuàng)新細胞生物學發(fā)展基金會理事長、中國神經(jīng)科學學會理事、中國細胞生物學學會理事、上海市神經(jīng)科學會常務理事。

　　細胞內(nèi)的蛋白質和RNA合成后要被運輸?shù)讲煌膮^(qū)域發(fā)揮作用，神經(jīng)元是一種特化的細胞，除了胞體它還具有長的軸突和樹突，因此蛋白質和RNA在細胞內(nèi)的長距離運輸就更為重要。我們近期的研究對兩部分的研究內(nèi)容感興趣，一方面是細胞內(nèi)運輸?shù)能壍牢⒐苁芪⒐艿鞍酌艽a(翻譯后修飾和亞型)的調控及對神經(jīng)元發(fā)育和神經(jīng)系統(tǒng)疾病的影響，另一方面是神經(jīng)元中非編碼RNA的運輸和調控機制以及在感覺傳遞和神經(jīng)元發(fā)育中的生理意義。

　　微管是細胞內(nèi)物質轉運的軌道，使得生長必須的蛋白質、RNA以及膜結構源源不斷的往末梢運輸，從而幫助神經(jīng)元軸突快速的生長。在神經(jīng)元發(fā)育過程中，微管蛋白及微管結構會不斷受到細胞內(nèi)分子和外界信號的調控，影響微管的聚合或解聚。微管功能調控在神經(jīng)元極性形成和軸突生長的過程中起著至關重要的作用。我們將圍繞微管蛋白密碼，鑒定微管蛋白翻譯后修飾和微管蛋白亞型對微管功能的調控作用，并揭示其在神經(jīng)元內(nèi)物質運輸、神經(jīng)系統(tǒng)發(fā)育(神經(jīng)元生長、極性形成和遷移)和神經(jīng)系統(tǒng)疾病中的重要作用。

　　非編碼RNA主要包括微小RNA (miRNA)和長鏈非編碼RNA(lncRNA)等，它們具有高度的組織特異性，并通過多種機制發(fā)揮調控作用。在初級感覺神經(jīng)元發(fā)育和感覺信息傳遞中，非編碼RNA的運輸和定位受到外界信號以及RNA結合蛋白等分子的精確調控。我們通過鑒定神經(jīng)元軸突特異分布的miRNA和lncRNA以及細胞類型特異定位的lncRNA，揭示軸突富集非編碼RNA以及細胞類型特異性的lncRNA在神經(jīng)元軸突發(fā)育以及感覺信息傳遞中的功能和作用機制。

1. Xie X, Wang SG, Li MY, Diao L, Pan XY, Chen JJ, Zhang X, Feng WF* and?Bao L*. (2021) α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation.?Nat Commun, 12: 4113.
2. Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, Bai M, Jiao Y, Yang Y, Hu X, Cheng T, Lu Q, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu J, Xiao HS, Qiu ZL, Li J, Wang Z, Hui J,?Bao L* and Zhang X*. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability.?eLife, 10: e63021.
3. Wei MY, Huang JS, Li GW, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L,?Bao L* and Wang B*.?(2021) Axon-enriched lincRNA?ALAE?is required for axon elongation?via?regulating local mRNA translation.?Cell Rep, 35: 109053.
4. Feng WF, Liu R, Xie X, Diao L, Gao NN, Cheng JK, Zhang X, Li Y and?Bao L*. (2021) SUMOylation of α-tubulin is a novel modification regulating microtubule dynamics.?J Mol Cell Biol, 13: 91–103.
5. Dong F, Shi HX, Yang L, Xue HQ, Wei MY, Zhong YQ,?Bao L* and Zhang X*. (2020) FGF13 is required for histamine-induced itch sensation by interaction with Na_V1.7.?J Neurosci, 40: 9589-9601.
6. Li JY, Shi HX, Liu H, Dong F, Liu ZP, Lu YJ, Chen LN, Bao L* and Xu Zhang*. (2020) Nerve injury-induced neuronal PAP-I maintains neuropathic pain by activating spinal microglia. J Neurosci, 40: 297-310.
7. Wei D, Gao NN, Li L, Zhu JX, Diao L, Huang JS, Han QJ, Wang SG, Xue HQ, Wang Q, Wu QF, Zhang X and Bao L*. (2018) α-Tubulin acetylation restricts axon overbranching by dampening microtubule plus-end dynamics in neurons. Cerebral Cortex, 28: 3332-3346.
8. Wang B and?Bao L*. (2017) Axonal microRNAs: localization, function and regulatory mechanism during axon development.?J. Mol. Cell Biol., 9: 82-90.
9. Yang L, Dong F, Yang Q, Yang PF, Wu R, Wu QF, Wu D, Li CL, Zhong YQ, Lu YJ, Cheng X, Xu FQ, Chen L,?Bao L?and Zhang X. (2017) FGF13 selectively regulates heat nociception by interacting with Na_v1.7.?Neuron, 93: 806-821.
10. Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and?Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting?Map1b?and?Calm1.?Cell Reports, 13: 1-14.
11. Chen XQ, Zhu JX, Wang Y, Zhang X and?Bao L*. (2014) CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor.?J. Mol. Cell Biol., 6: 140-153.
12. Su YY, Ye M, Li?L, Liu C, Pan J, Liu WW, Jiang?Y, Jiang?XY, Zhang?X, Shu?Y and?Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Na_v1.8.?J. Neurosci., 33: 17884-17896.
13. Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and?Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling.?J. Cell Sci., 126: 542-553.
14. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and?Bao L*. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons.?J. Neurosci.,?32: 12673-12683.
15. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and?Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X₃?receptor signals in primary sensory neurons.?Cell Res.,?22: 677-696.
16. Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X,?Bao L?and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration.?Cell, 149:1549-1564.
17. He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ,?Bao L* and Zhang X*. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation.?Neuron, 69: 120-131.
18. Li Q, Su YY, Wang H, Li L, Wang Q and?Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Na_v1.8 and promote calnexin-dependent channel degradation.?J. Biol. Chem.,?285: 32977-32987.
19. Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, H？kfelt TGM*,?Bao L*, and Zhang X*. (2010) Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons.?Proc Natl Acad Sci U S A., 107: 13117-13122
20. Liu C, Li Q, Su YY and?Bao L* (2010) Prostaglandin E₂?promotes Na_v1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway.?Traffic, 11: 405-417.
21. Zhang X*,?Bao L* and Ma GQ (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathways.?Progress in Neurobiology, 90: 276-283. (Review)
22. Ma GQ, Wang B, Wang HB, Wang Q and?Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles.?Traffic, 9: 2165–2179.
23. Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and?Bao L* (2008) Voltage-gated sodium channel Na_v1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit.?J. Cell Sci.?121: 3243-3252

合影