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　　2004年畢業(yè)于中科院生物化學(xué)與細(xì)胞生物學(xué)研究所，獲理學(xué)博士學(xué)位。2004年赴美國(guó)哈佛大學(xué)醫(yī)學(xué)院Dana-Farber腫瘤研究所從事免疫學(xué)研究，先后為博士后(受美國(guó)關(guān)節(jié)炎基金會(huì)資助)，instructor。2009年11月回生化與細(xì)胞所工作，擔(dān)任研究員與研究組長(zhǎng)，現(xiàn)任所長(zhǎng)助理、分子生物學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室副主任、中國(guó)生物化學(xué)與分子生物學(xué)會(huì)副秘書長(zhǎng)。先后入選國(guó)家杰出青年基金、科技部中青年科技創(chuàng)新領(lǐng)軍人才、上海市科委優(yōu)秀學(xué)術(shù)帶頭人計(jì)劃;成果入選中國(guó)科學(xué)十大進(jìn)展和中國(guó)生命科學(xué)十大進(jìn)展;獲談家楨生命科學(xué)獎(jiǎng)創(chuàng)新獎(jiǎng)、中源協(xié)和生命醫(yī)學(xué)獎(jiǎng)、全國(guó)優(yōu)秀科技工作者、上海青年科技英才等獎(jiǎng)項(xiàng)。

• 　　圖3. 基于膽固醇代謝調(diào)控的腫瘤免疫治療新方法。膽固醇酯化酶ACAT1可以將細(xì)胞內(nèi)的游離膽固醇轉(zhuǎn)化為膽固醇酯。抑制CD8+ T細(xì)胞的ACAT1活性可以使細(xì)胞質(zhì)膜的游離膽固醇水平上升，從而使得TCR信號(hào)增強(qiáng)并讓殺傷性免疫突觸更成熟。T細(xì)胞腫瘤抗原免疫應(yīng)答由此變得更加高效。

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