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首頁(yè) 全所PI名錄
  • 鄒衛(wèi)國(guó)
  • 研究員，研究組長(zhǎng)，博士生導(dǎo)師
  • E-mail: zouwg94@@sibcb.ac.cn
  • 實(shí)驗(yàn)室主頁(yè): 
    個(gè)人簡(jiǎn)介：
  • 1998年本科畢業(yè)于南開(kāi)大學(xué)生物化學(xué)系，2003年中科院生物化學(xué)與細(xì)胞生物學(xué)研究所獲得理學(xué)博士學(xué)位。隨后在美國(guó)Scripps研究所和美國(guó)哈佛大學(xué)公共衛(wèi)生學(xué)院進(jìn)行博士后研究(受美國(guó)白血病淋巴瘤協(xié)會(huì)資助)。2009年獲選哈佛大學(xué)公共衛(wèi)生學(xué)院Yerby Fellow。2012年獲聘美國(guó)康納爾大學(xué)和紐約州立大學(xué)布法羅分校Tenure Track助理教授職位。2012年8月回中科院生物化學(xué)與細(xì)胞生物學(xué)研究所工作，任研究員，研究組長(zhǎng)，博士生導(dǎo)師。獲得國(guó)家自然科學(xué)基金委杰出青年科學(xué)基金資助，國(guó)家科技部基礎(chǔ)科學(xué)重大研究計(jì)劃子課題負(fù)責(zé)人，中國(guó)科學(xué)院戰(zhàn)略性先導(dǎo)科技專項(xiàng)（B類）子課題負(fù)責(zé)人，中華醫(yī)學(xué)會(huì)骨科分會(huì)再生醫(yī)學(xué)青年委員會(huì)組長(zhǎng)，中華醫(yī)學(xué)會(huì)骨礦鹽與骨質(zhì)疏松分會(huì)基礎(chǔ)組常委，中國(guó)生物工程學(xué)會(huì)轉(zhuǎn)化醫(yī)學(xué)分會(huì)常委等。
    社會(huì)任職：
    研究方向：
  • 間充質(zhì)干細(xì)胞與疾病
    研究工作：
  • 間充質(zhì)干細(xì)胞（mesenchymal stem cells,MSC）是一種多能干細(xì)胞，可以分化成成骨細(xì)胞、軟骨細(xì)胞、脂肪細(xì)胞、肌肉細(xì)胞等。同時(shí)，間充質(zhì)干細(xì)胞來(lái)源方便，易于分離、培養(yǎng)、擴(kuò)增和純化，可以作為組織器官損傷修復(fù)的種子細(xì)胞。間充質(zhì)干細(xì)胞是國(guó)內(nèi)外用于干細(xì)胞臨床試驗(yàn)使用最多的細(xì)胞。間充質(zhì)干細(xì)胞向不同組織細(xì)胞的分化受到多種遺傳因素和表觀遺傳因素的影響，受到包括BMP、Wnt、Hedgehog等多種信號(hào)途徑的調(diào)控。調(diào)控因素的異常，導(dǎo)致多種疾病，包括多種先天性發(fā)育畸形、骨質(zhì)疏松癥、骨性關(guān)節(jié)炎等骨科相關(guān)疾病。
    ?
    本研究組綜合運(yùn)用生物化學(xué)、分子生物學(xué)和動(dòng)物模型等多種研究手段，通過(guò)建立間充質(zhì)干細(xì)胞向多種細(xì)胞分化的體外高通量篩選系統(tǒng)，研究間充質(zhì)干細(xì)胞增殖與分化的分子機(jī)理，以及構(gòu)建轉(zhuǎn)基因與基因敲除小鼠研究與間充質(zhì)干細(xì)胞相關(guān)的多種疾病的致病機(jī)理。實(shí)驗(yàn)室近期研究方向包括：
    1）研究間充質(zhì)干細(xì)胞所受到的表觀調(diào)控在骨關(guān)節(jié)炎、骨質(zhì)疏松及骨損傷修復(fù)過(guò)程中的作用。
    2）研究間充質(zhì)干細(xì)胞的衰老與骨疾病的關(guān)聯(lián)及分子基礎(chǔ)。
    3）研究機(jī)械力對(duì)于間充質(zhì)干細(xì)胞功能及骨結(jié)構(gòu)的調(diào)控機(jī)制。
    4）研究骨損傷修復(fù)中間充質(zhì)干細(xì)胞的起源、增殖及命運(yùn)決定的機(jī)制。

    承擔(dān)科研項(xiàng)目情況：
    代表論著：
    1. Wang L#, You X#, Ruan D#, Shao R, Dai H, Shen W, Xu G, Liu W, Zou W*. (2022) TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 13(1):4709.
    2. Gao B#, Jiang B#, Xing W, Xie Z, Luo Z*, Zou W*. (2022) Discovery and application of postnatal nucleus pulposus progenitors essential for intervertebral disc homeostasis and degeneration. Advanced Science. 9(13): e2104888.
    3. Suo J #, Zou S#, Wang J#, Han Y, Zhang L, Lv C, Jiang B, Ren Q, Chen L, Yang L, Ji P, Zheng X*, Hu P*, Zou W*. (2022) The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research. 10(1): 31.
    4. Wang L, You X, Zhang L, Zhang C, Zou W*. (2022) Mechanical regulation of bone remodeling. Bone Research. 10(1): 16.
    5. Shao R#, Zhang Z#, Xu Z, Ouyang H, Wang L, Ouyang H, Greenblatt M, Chen X, Zou W*. (2021) H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Research. 9(1): 30.
    6. Feng H#, Xing W#, Han W#, Sun J, Kong M, Gao B, Yang Y, Yin Z, Chen X, Zhao Y, Bi Q, Zou W*. (2020) Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 130(12): 6354-6365.
    7. Sun J#, Feng H#, Xing W, Han Y, Suo J, Yallowitz A, Qian N, Shi Y, Greenblatt M, Zou W*. (2020) Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Science Advances. 6(45): eaaz1410.
    8. Suo J#, Feng X#, Li J, Wang J, Wang Z*, Zhang L*, Zou W*. (2020) VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances. 6(43): eaba4147.
    9. Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W*. (2020) Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature Communications. 11: 282.
    10. Han Y, Feng H, Sun J, Liang X, Wang Z, Xing W, Dai Q, Yang Y, Han A, Wei Z, Bi Q, Ji H, Kang T *, Zou W*. (2019) Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. Journal of Clinical Investigation. 129: 1895-1909.
    11. Bai M, Han Y, Wu Yu, Liao J, Li L, Wang L, Li Q, Xing W, Chen L, Zou W*, Li J*. (2019) Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biology. 17: e3000350.
    12. Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W*. (2018) H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 16: e2006522.
    13. Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
    14. Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14.
    15. Dai Q, Xu Z, Ma X, Niu N, Zhou S, Xie F, Jiang L, Wang J*, Zou W*. (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death and Differentiation. 24: 1886–1899.
    16. Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher L, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
    17. Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. (2016) Cdh1 regulates Craniofacial Development via APC-dependent Activation of Goosecoid. Cell Research. 26: 699-712.
    18. Liu Z, Yao X, Yan G, Xu Y, Yan J, Zou W*, Wang G*. (2016) Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications. 7: 11149.
    19. Zou W*, Greenblatt M, Brady N, Lotinun S, Zhai B, de Rivera H, Singh A, Sun J, Gygi S, Baron R, Glimcher L, Jones D. (2013) The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. Journal of Experimental Medicine. 210: 1793-806.
    20. Zou W, Chen X., Shim J, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher L, Jones D*. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13: 59–65.
    21. Zou W#, Greenblatt M#, Shim J, Kant S, Zhai B, Brady B, Hu D, Gygi S, Davis R, Jones D, Glimcher L*. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. Journal of Clinical Investigation. 121: 4383-92.
    22. Wan L#, Zou W#, Gao D, Inuzuka H, Drapp R, Shaik S, Eguren M, Hu D, Malumbres M, Glimcher L, Wei W*. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44: 721-33.
    獲獎(jiǎng)及榮譽(yù)：
    研究組成員：